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Titolo:
Ecstasy - long-term effects on the human central nervous system revealed by positron emission tomography
Autore:
Obrocki, J; Buchert, R; Vaterlein, O; Thomasius, R; Beyer, W; Schiemann, T;
Indirizzi:
Univ Hamburg Hosp, Dept Psychiat & Psychotherapy, D-20246 Hamburg, GermanyUniv Hamburg Hosp Hamburg Germany D-20246 rapy, D-20246 Hamburg, Germany Univ Hamburg Hosp, Dept Nucl Med, D-20246 Hamburg, Germany Univ Hamburg Hosp Hamburg Germany D-20246 Med, D-20246 Hamburg, Germany Univ Hamburg Hosp, Inst Math & Comp Sci Med, D-20246 Hamburg, Germany UnivHamburg Hosp Hamburg Germany D-20246 Med, D-20246 Hamburg, Germany
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 175, anno: 1999,
pagine: 186 - 188
SICI:
0007-1250(199908)175:<186:E-LEOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED SEROTONIN DEFICITS; PARTIAL RECOVERY; 52-WEEK PERIOD; MDMA ECSTASY; NEUROTOXICITY; BRAIN; VALIDATION; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Obrocki, J Univ Hamburg Hosp, Dept Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Hosp Martinistr 52 Hamburg GermanyD-20246 ermany
Citazione:
J. Obrocki et al., "Ecstasy - long-term effects on the human central nervous system revealed by positron emission tomography", BR J PSYCHI, 175, 1999, pp. 186-188

Abstract

Background The main psychotropic agent of the popular illicit drug ecstasyis 3,4-methylenedioxymethamphetamine (MDMA). In the light of animal studies and examinations of human cerebrospinal fluid, MDMA is suspected of causing neurotoxic lesions to the serotonergic system. Aims To postulate a relationship between ecstasy use and lasting alterations to the cerebral glucose metabolic rate. Method Positron emission tomography (PET) with 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) was performed on seven ecstasy users and seven subjects without any known history of illicit drug use. Data were compared for a limited number of brain regions. Results By comparison with the control group, the glucose metabolic uptakeof the ecstasy user group was altered within the amygdala, hippocampus andBrodmann's area II. Conclusions The results suggest the possibility that ecstasy use has lasting effects on central neuronal activity in humans. Declaration of interest No external funding. No conflict of interest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:20:55