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Titolo:
Feline immunodeficiency virus envelope protein (FIVgp120) causes electrophysiological alterations in rats
Autore:
Prospero-Garcia, O; Huitron-Resendiz, S; Casalman, SC; Sanchez-Alavez, M; Diaz-Ruiz, O; Navarro, L; Lerner, DL; Phillips, TR; Elder, JH; Henriksen, SJ;
Indirizzi:
Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Neurosci Grp, Mexico City04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 ty04510, DF, Mexico Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 836, anno: 1999,
pagine: 203 - 209
SICI:
0006-8993(19990731)836:1-2<203:FIVEP(>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; HIV-INFECTION; SEROPOSITIVE PATIENTS; AIDS DEMENTIA; NEURONAL LOSS; SLEEP; BRAIN; ABNORMALITIES; TYPE-1; INJURY;
Keywords:
AIDS; dementia; sleep; visual evoked potential; auditory evoked potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Prospero-Garcia, O Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Neurosci Grp, Apdo Postal70-250, Mexico City 04510, DF, Mexico Univ Nacl AutonomaMexico Apdo Postal 70-250 Mexico City DF Mexico 04510
Citazione:
O. Prospero-Garcia et al., "Feline immunodeficiency virus envelope protein (FIVgp120) causes electrophysiological alterations in rats", BRAIN RES, 836(1-2), 1999, pp. 203-209

Abstract

Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV+ subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. TheHIV-derived glycoprotein 120 has been postulated as a neurotoxic; therefore, it may be playing a crucial role in the generation of BSAEP and VEP, as well as in sleep disturbances. To study the role of the virus-derived proteins on the development of these electrophysiological signals' alterations, we have used the feline immunodeficiency virus (FIV)-derived gp120 and evaluated the changes in these electrophysiological signals. We employed 15 adult male Sprague-Dawley rats (250-350 g), chronically implanted for evoked potential and sleep recordings. Results showed that the i.c.v. administration of FIVgp120 (5 ng/10 mu l) produces changes in the latency of both cortical auditory evoked potentials (CAEPs) and VEPs and a decrease in both REM sleep and SWS. These data support the notion that FIVgp120 is neurotoxic to the central nervous system of cats and rats and that this protein suffices to cause electrophysiological alterations. In addition, it suggests that a similar effect may be occurring in humans as a result of HIVgp120's neurotoxic effects. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 16:07:23