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Titolo:
Thrombotic microangiopathy following allogeneic bone marrow transplantation
Autore:
Takatsuka, H; Takemoto, Y; Okamoto, T; Fujimori, Y; Tamura, S; Wada, H; Okada, M; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka, Japan Kinki Univ Osaka Japan Univ, Sch Med, Dept Internal Med 3, Osaka, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 3, volume: 24, anno: 1999,
pagine: 303 - 306
SICI:
0268-3369(199908)24:3<303:TMFABM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOLYTIC-UREMIC SYNDROME; VERSUS-HOST DISEASE; THROMBOCYTOPENIC PURPURA; INTERFERON-GAMMA; TH CELLS; INTERLEUKIN-12; CYCLOSPORINE; IL-12; THROMBOMODULIN; PROPHYLAXIS;
Keywords:
bone marrow transplantation; thrombotic microangiopathy; interleukin-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
H. Takatsuka et al., "Thrombotic microangiopathy following allogeneic bone marrow transplantation", BONE MAR TR, 24(3), 1999, pp. 303-306

Abstract

Thrombotic microangiopathy is one of the complications of bone marrow transplantation and is related to other complications such as graft-versus-hostdisease, veno-occlusive disease, diffuse alveolar hemorrhage, and cytomegalovirus infection. Thrombotic microangiopathy occurred in three out of 12 patients who underwent allogeneic bone marrow transplantation over the past 1 year at our department. We compared the changes in cytokines and other molecules between patients with and without microangiopathy from before conditioning to the early post-transplantation period. All three patients with microangiopathy showed a significant increase of interleukin-12 at the time of leukocyte recovery after transplantation (two-way layout analysis of variance; P < 0.05), while none of the patients without microangiopathy showedan increase of interleukin-12. No significant differences were found between the two groups with respect to the other cytokines and molecules that were tested. These findings suggested that thrombotic microangiopathy might be predicted at an early stage after bone marrow transplantation by detecting an increase of interleukin-12 at the time of leukocyte recovery. The possibility that thrombotic microangiopathy is related to inflammation or autoimmunity was also suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:32:32