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Titolo:
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Autore:
Armstrong, HM; Wong, F; Holmes, MA; Sinclair, PJ; Goulet, MT; Dumont, FJ; Staruch, M; Koprak, S; Peterson, LB; Rosa, R; Wilusz, MB; Wiederrecht, GJ; Cryan, JG; Wyvratt, MJ; Parsons, WH;
Indirizzi:
Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs RahwayNJ USA 07065 s, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Immunol Res, Rahway, NJ 07065 USA Merck Res Labs Rahway NJ USA 07065 Dept Immunol Res, Rahway, NJ 07065 USA Merck Res Labs, Dept Mol Pharmacol, Rahway, NJ 07065 USA Merck Res Labs Rahway NJ USA 07065 pt Mol Pharmacol, Rahway, NJ 07065 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 14, volume: 9, anno: 1999,
pagine: 2089 - 2094
SICI:
0960-894X(19990719)9:14<2089:PICEDO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TACROLIMUS-RELATED IMMUNOSUPPRESSANT; CYCLOSPORINE-A; FK-506; CALCINEURIN; ACTIVATION; DISTINCT; CYCLOPHILIN; RAPAMYCIN; FK506;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Armstrong, HM Merck Res Labs, Dept Med Chem, POB 2000, Rahway, NJ 07065 USA Merck Res Labs POB 2000 Rahway NJ USA 07065 ay, NJ 07065 USA
Citazione:
H.M. Armstrong et al., "Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.", BIOORG MED, 9(14), 1999, pp. 2089-2094

Abstract

The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:10:31