Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MEMBRANE AND MORPHOLOGICAL-CHANGES IN APOPTOTIC CELLS REGULATED BY CASPASE-MEDIATED ACTIVATION OF PAK2
Autore:
RUDEL T; BOKOCH GM;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,10550 N TORREY PINES RD LA JOLLACA 92037 SCRIPPS CLIN & RES INST,DEPT IMMUNOL LA JOLLA CA 92037
Titolo Testata:
Science
fascicolo: 5318, volume: 276, anno: 1997,
pagine: 1571 - 1574
SICI:
0036-8075(1997)276:5318<1571:MAMIAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW CYTOMETRIC DETECTION; PHOSPHATIDYLSERINE EXPRESSION; POLY(ADP-RIBOSE) POLYMERASE; ANNEXIN-V; PROTEASE; DEATH; INTERLEUKIN-1-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Rudel e G.M. Bokoch, "MEMBRANE AND MORPHOLOGICAL-CHANGES IN APOPTOTIC CELLS REGULATED BY CASPASE-MEDIATED ACTIVATION OF PAK2", Science, 276(5318), 1997, pp. 1571-1574

Abstract

Apoptosis of Jurkat T cells induced the caspase-mediated proteolytic cleavage of p21-activated kinase 2 (PAK2). Cleavage occurred between the amino-terminal regulatory domain and the carboxyl-terminal catalytic domain, which generated a constitutively active PAK2 fragment. Stable Jurkat cell lines that expressed a dominant-negative PAK mutant wereresistant to the Fas-induced formation of apoptotic bodies, but had an enhanced externalization of phosphatidlyserine at the cell surface. Thus, proteolytic activation of PAK2 represents a guanosine triphosphatase-independent mechanism of PAK regulation that allows PAK2 to regulate morphological changes that are seen in apoptotic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:37:10