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Titolo:
Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome
Autore:
Bleyl, JU; Ragaller, M; Tscho, U; Regner, M; Kanzow, M; Hubler, M; Rasche, S; Albrecht, M;
Indirizzi:
Tech Univ Dresden, Dept Anesthesiol & Intens Care Med, D-8027 Dresden, Germany Tech Univ Dresden Dresden Germany D-8027 re Med, D-8027 Dresden, Germany Tech Univ Dresden, Fac Med, D-8027 Dresden, Germany Tech Univ Dresden Dresden Germany D-8027 ac Med, D-8027 Dresden, Germany
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 2, volume: 91, anno: 1999,
pagine: 461 - 469
SICI:
0003-3022(199908)91:2<461:VPIOAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL LIQUID VENTILATION; ACUTE LUNG INJURY; GAS-EXCHANGE; OLEIC-ACID; MECHANICAL VENTILATION; FAILURE; PERFLUBRON; LAVAGE; EDEMA; ARDS;
Keywords:
gas exchange; innovative application; lung injury; lung mechanics; perfluorocarbon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bleyl, JU Carl Gustav Carus Univ Hosp, Dept Anesthesiol & Intens Care Med,Fetscherstr 74, D-01307 Dresden, Germany Carl Gustav Carus Univ Hosp Fetscherstr 74 Dresden Germany D-01307
Citazione:
J.U. Bleyl et al., "Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome", ANESTHESIOL, 91(2), 1999, pp. 461-469

Abstract

Background: Perfluorocarbon liquids are being used experimentally and in clinical trials for the treatment of acute lung injury. Their resemblance toinhaled anesthetic agents suggests the possibility of application by vaporization. The authors' aim was to develop the technical means for perfluorocarbon vaporization and to investigate its effects on gas exchange and lung function in an ovine model of oleic acid-induced lung injury. Methods: Two vaporizers were calibrated for perfluorohexane and connected sequentially in the inspiratory limb of a conventional anesthetic machine. Twenty sheep were ventilated in a volume controlled mode at an inspired oxygen fraction of 1.0. Lung injury was induced by intravenous injection of 0.1 mi oleic acid per kilogram body weight. Ten sheep were treated with vaporized perfluorohexane for 30 min and followed for 2 h; 10 sheep served as controls. Measurements of blood gases and respiratory and hemodynamic parameters were obtained at regular intervals. Results: Vaporization of perfluorohexane significantly increased arterial oxygen tension 30 min after the end of treatment (P < 0.01). At 2 h after treatment the oxygen tension was 376 +/- 182 mmHg (mean +/- SD). Peak inspiratory pressures (P < 0.01) and compliance (P < 0.01) were significantly reduced from the end of the treatment interval onward. Conclusion: Vaporization is a new application technique for perfluorocarbon that significantly improved oxygenation and pulmonary function in oleic acid-induced lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 22:10:15