Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Myocardial infarction and remodeling in mice: effect of reperfusion
Autore:
Michael, LH; Ballantyne, CM; Zachariah, JP; Gould, KE; Pocius, JS; Taffet, GE; Hartley, CJ; Pham, TT; Daniel, SL; Funk, E; Entman, ML;
Indirizzi:
Baylor Coll Med, Dept Med, Cardiovasc Sci Sect, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 vasc Sci Sect, Houston, TX 77030 USA Baylor Coll Med, DeBakey Heart Ctr, Houston, TX 77030 USA Baylor Coll MedHouston TX USA 77030 key Heart Ctr, Houston, TX 77030 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 46, anno: 1999,
pagine: H660 - H668
SICI:
0363-6135(199908)46:2<H660:MIARIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; 12-MONTH FOLLOW-UP; PLASMINOGEN-ACTIVATOR; CANINE MYOCARDIUM; RANDOMIZED TRIAL; HEART-FAILURE; MAST-CELLS; DOPPLER; PERFORMANCE; THROMBOLYSIS;
Keywords:
coronary artery occlusion; nuclear imaging; hypertrophy; systolic and diastolic function; ejection fraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Michael, LH Baylor Coll Med, Dept Med, Cardiovasc Sci Sect, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
L.H. Michael et al., "Myocardial infarction and remodeling in mice: effect of reperfusion", AM J P-HEAR, 46(2), 1999, pp. H660-H668

Abstract

Anatomic and functional changes after either a permanent left anterior descending coronary artery occlusion (PO) or 2 h of occlusion followed by reperfusion (OR) in C57BL/6 mice were examined and compared with those in sham-operated mice. Both interventions generated infarcts comprising 30% of the left ventricle (LV) measured at 24 h and equivalent suppression of LV ejection velocity and filling velocity measured by Doppler ultrasound at 1 wk. Serial follow-up revealed that the ventricular ejection velocity and fillingvelocity returned to the levels of the sham-operated controls in the OR group at 2 wk and remained there; in contrast, PO animals continued to display suppression of both systolic and diastolic function. In contrast, ejection fractions of PO and OR animals were depressed equivalently (50% from sham-operated controls), Anatomic reconstruction of serial cross sections revealed that the percentage of the LV endocardial area overlying the ventricular scar (expansion ratio) was significantly larger in the PO group vs. the OR group (18 +/- 1.7% vs. 12 +/- 0.9%, P < 0.05). The septum that was never involved in the infarction had a significantly (P < 0.002) increased mass in PO animals (22.5 +/- 1.08 mg) vs. OR (17.8 +/- 1.10 mg) or sham control (14.8 +/- 0.99 mg) animals. Regression analysis demonstrated that the extentof septal hypertrophy correlated with LV expansion ratio. Thus late reperfusion appears to reduce the degree of infarct expansion even under circumstances in which it no longer can alter infarct size. We suggest that reperfusion promoted more effective ventricular repair, less infarct expansion, and significant recovery or preservation of ventricular function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 09:10:56