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Titolo:
Myocardial tumor necrosis factor-alpha secretion in hypertensive and heartfailure-prone rats
Autore:
Bergman, MR; Kao, RH; McCune, SA; Holycross, BJ;
Indirizzi:
Ohio State Univ, Coll Med, Dept Med Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Med Biochem, Columbus, OH 43210 USA Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Coll Pharm, Columbus, OH 43210 USA Ohio State Univ, Coll Food Agr & Environm Sci, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 i & Technol, Columbus, OH 43210 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 46, anno: 1999,
pagine: H543 - H550
SICI:
0363-6135(199908)46:2<H543:MTNFSI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAILING HUMAN HEART; GENE-EXPRESSION; CELLS; INTERLEUKIN-1-BETA; HYPERTROPHY; INHIBITORS; RECEPTORS; SHOCK; AGE;
Keywords:
spontaneously hypertensive rats; SHHF/Mcc-fa(cp) rats; phosphodiesterase inhibitors; amrinone; RO-201724;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Holycross, BJ Ohio State Univ, Coll Med, Dept Med Biochem, 333 Hamilton Hall,1645 Neil Ave, Columbus, OH 43210 USA Ohio State Univ 333 Hamilton Hall,1645 Neil Ave Columbus OH USA 43210
Citazione:
M.R. Bergman et al., "Myocardial tumor necrosis factor-alpha secretion in hypertensive and heartfailure-prone rats", AM J P-HEAR, 46(2), 1999, pp. H543-H550

Abstract

Acute increases in blood pressure (BP) increase myocardial tumor necrosis factor (TNF)-alpha production, but it is not known whether chronic hypertensive stress elevates myocardial TNF-alpha production, possibly contributingto cardiac remodeling, decreased cardiac function, and faster progression to heart failure. BP, cardiac function, and size were evaluated in normotensive [Sprague-Dawley (SD)], spontaneously hypertensive (SHR), and spontaneously hypertensive heart failure-prone (SHHF) rats at 6, 12, 15, and 18 mo of age and in failing SHHF. Left ventricular tissues were evaluated for secretion of bioactive TNF-alpha and inhibition of TNF-alpha secretion by phosphodiesterase inhibitors. All ventricles secreted bioactive and immunoreactive TNF-alpha, but secretion decreased with age. SHR and SHHF rats secreted more TNF-alpha than SD rats at 6 mo of age, but only failing SHHF rats secreted significantly more TNF-alpha at 18 mo. Amrinone inhibited TNF-alpha secretion in all rats and was less potent but more efficacious than RO-201724in all strains. TNF-alpha secretion correlated with BP and left ventricular mass in 6-mo-old rats, but this relationship disappeared with age. Results suggest that hypertension and/or cardiac remodeling is associated with elevated myocardial TNF-alpha, and, although hypertension, per se, did not maintain elevated cardiac TNF-alpha levels, SHHF rats increase TNF-alpha production during the end stages of failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:42:10