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Titolo:
Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation
Autore:
Chatham, JC; Gao, ZP; Forder, JR;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Magnet Resonance Res, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ce Res, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 40, anno: 1999,
pagine: E342 - E351
SICI:
0193-1849(199908)40:2<E342:IO1WOD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED WORKING HEARTS; RAT-HEART; GLUCOSE-OXIDATION; PERFUSED HEARTS; METABOLISM; SUBSTRATE; TURNOVER; CARDIOMYOPATHY; MELLITUS; LACTATE;
Keywords:
palmitate; C-13-nuclear magnetic resonance spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Chatham, JC Johns Hopkins Univ, Sch Med, Dept Radiol, Div Nucl Magnet Resonance Res, 217 Traylor Bldg,720 Rutland Ave, Baltimore, MD 21205 USA Johns Hopkins Univ 217 Traylor Bldg,720 Rutland Ave Baltimore MD USA 21205
Citazione:
J.C. Chatham et al., "Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation", AM J P-ENDO, 40(2), 1999, pp. E342-E351

Abstract

The aim of this study was to investigate the effect of increasing exogenous palmitate concentration on carbohydrate and palmitate oxidation in heartsfrom control and 1-wk diabetic rats. Hearts were perfused with glucose, [3-C-13]lactate, and [U-C-13]palmitate. Substrate oxidation rates were determined by combining C-13-NMR glutamate isotopomer analysis of tissue extractswith measurements of oxygen consumption. Carbohydrate oxidation was markedly depressed after diabetes in the presence of low (0.1 mM) but not high (1.0 mM) palmitate concentration. Increasing exogenous palmitate concentration 10-fold resulted in a 7-fold increase in the contribution of palmitate toenergy production in controls but only a 30% increase in the diabetic group. Consequently, at 0.1 mM palmitate, the rate of fatty acid oxidation was higher in the diabetic group than in controls; however, at 1.0 mM fatty acid oxidation, it was significantly depressed. Therefore, after 1 wk of diabetes, the major differences in carbohydrate and fatty acid metabolism occur primarily at low rather than high exogenous palmitate concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:07:34