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Titolo:
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
Autore:
Powell, DW; Mifflin, RC; Valentich, JD; Crowe, SE; Saada, JI; West, AB;
Indirizzi:
Univ Texas, Med Branch, Dept Internal Med, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 t Internal Med, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Physiol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 , Dept Physiol, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Biophys & Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 ophys & Pathol, Galveston, TX 77555 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 2, volume: 46, anno: 1999,
pagine: C183 - C201
SICI:
0363-6143(199908)46:2<C183:MIISM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING-GROWTH-FACTOR; INFLAMMATORY BOWEL-DISEASE; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE CELLS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FAMILIAL ADENOMATOUS POLYPOSIS; EPITHELIAL BARRIER FUNCTION; GASTROINTESTINAL STROMAL TUMORS; PROSTAGLANDIN G/H SYNTHASE-1; GASTRIC-MUCOSAL LESIONS;
Keywords:
interstitial cells of Cajal; cyclooxygenase; chemoprevention; wound repair; fibrosis; electrolyte transport; immunophysiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
233
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, DW Univ Texas, Med Branch, Dept Internal Med, 4-108 John Sealy Annex,0567,301Univ Blvd, Galveston, TX 77555 USA Univ Texas 4-108 John Sealy Annex,0567,301 Univ Blvd Galveston TX USA 77555
Citazione:
D.W. Powell et al., "Myofibroblasts. II. Intestinal subepithelial myofibroblasts", AM J P-CELL, 46(2), 1999, pp. C183-C201

Abstract

Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cellsof Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor (SCF), through expression of PDGF receptors and the SCF receptor c-hit. ISEMF have been shown to play important roles in the organogenesis of the intestine, and growth factors and cytokines secreted by these cells promote epithelial restitution andproliferation, i.e,, wound repair. Their role in the fibrosis of Crohn's disease and collagenous colitis is being investigated. Through cyclooxygenase (COX)-1 and COX-2 activation, ISEMF augment intestinal ion secretion in response to certain secretagogues. By forming a subepithelial barrier to Nadiffusion, they create a hypertonic compartment that may account for the ability of the gut to transport fluid against an adverse osmotic gradient. Through the paracrine secretion of prostaglandins and growth factors (e.g., transforming growth factor-beta), ISEMF may play a role in colonic tumorigenesis and metastasis. COX-2 in polyp ISEMF may be a target for nonsteroidalanti-inflammatory drugs (NSAIDs), which would account for the regression of the neoplasms in familial adenomatous polyposis and the preventive effectof NSAIDs in the development of sporadic colon neoplasms. More investigation is needed to clarify the functions of these pleiotropic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:24:19