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Titolo:
Tissue transglutaminase antibodies in celiac disease
Autore:
Biagi, F; Ellis, HJ; Yiannakou, JY; Brusco, G; Swift, GL; Smith, PM; Corazza, GR; Ciclitira, PJ;
Indirizzi:
St Thomas Hosp, Rayne Inst, Gastroenterol Unit GKT, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Unit GKT, London SE1 7EH, England Llandough Hosp, Dept Gastroenterol, Cardiff, S Glam, Wales Llandough HospCardiff S Glam Wales astroenterol, Cardiff, S Glam, Wales Univ Aquila, Dept Internal Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 t Internal Med, I-67100 Laquila, Italy
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 8, volume: 94, anno: 1999,
pagine: 2187 - 2192
SICI:
0002-9270(199908)94:8<2187:TTAICD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN UMBILICAL-CORD; ENDOMYSIAL ANTIBODY; ANTIENDOMYSIUM ANTIBODIES; SCREENING-TEST; AUTOANTIBODIES; ANTIGLIADIN; AUTOANTIGEN; PREVALENCE; DEFICIENCY; ICEBERG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ciclitira, PJ St Thomas Hosp, Rayne Inst, Gastroenterol Unit GKT, Lambeth Palace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd LondonEngland SE1 7EH and
Citazione:
F. Biagi et al., "Tissue transglutaminase antibodies in celiac disease", AM J GASTRO, 94(8), 1999, pp. 2187-2192

Abstract

OBJECTIVE: Tissue transglutaminase is the antigen for antiendomysial antibodies, whose power in screening for celiac disease is well known. Our aim was to assess the efficacy of an ELISA assay for tissue transglutaminase antibodies. METHODS: Tissue transglutaminase antibodies were analyzed in serum from 39untreated celiac disease patients and 61 controls. Tissue transglutaminasewas used as antigen, and test sera analyzed by ELISA. Results higher than 0.6 optical density were considered positive, lower than 0.4 negative, and between 0.4 and 0.6 borderline. RESULTS: Optical density of the serum from the patients with untreated celiac disease (median: 1.41; range: 0.33-1.47) were significantly higher thanthe controls (median: 0.32; range: 0.17-0.68; p < 0.0001; 95% confidence interval 0.87-1.08). Thirty-three patients with untreated celiac disease were positive, 4 borderline, and 2 negative. Fifty-five controls were negative, 4 borderline, and 2 positive. If we consider borderline results to be positive, sensitivity is 94.8% and specificity 90.1%. None of the controls gave results higher than 0.7 optical density. Apart from the 2 negative patients with untreated celiac disease, the two groups overlapped only between 0.4 and 0.7 optical density. CONCLUSIONS: Because of the high sensitivity (approximate to 95%) and technical simplicity, tissue transglutaminase antibodies may prove useful for the screening of celiac disease in population at low or medium risk of celiac disease. To avoid duodenal biopsies in patients without celiac disease, the specificity of the screening procedure may be increased by confirming with antiendomysial antibodies by immunofluorescence on human umbilical cord in individuals with results between 0.4 and 0.7 optical density. (Am J Gastroenterol 1999;94: 2187-2192. (C) 1999 by Am. Cell. of Gastroenterology).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:27:45