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Titolo:
Dose and time dependent effects of ethanol on antioxidant system in rat testes
Autore:
Schlorff, EC; Husain, K; Somani, SM;
Indirizzi:
So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA
Titolo Testata:
ALCOHOL
fascicolo: 2-3, volume: 18, anno: 1999,
pagine: 203 - 214
SICI:
0741-8329(199906/07)18:2-3<203:DATDEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; FREE-RADICALS; GLUTATHIONE-PEROXIDASE; MATURING RAT; ALCOHOL; INJURY; LIVER; ASSAY; TRANSCRIPTION;
Keywords:
ethanol; antioxidant enzyme; glutathione; lipid peroxidation; testes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Somani, SM So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 gfield, IL 62794 USA
Citazione:
E.C. Schlorff et al., "Dose and time dependent effects of ethanol on antioxidant system in rat testes", ALCOHOL, 18(2-3), 1999, pp. 203-214

Abstract

This study was designed to investigate the dose as well as time dependent effects of ethanol on testicular antioxidant defense system in rats, Male Fischer 344 rats were administered ethanol at a dose of 2, 4, and 6 gm/kg orally and control received equal volume of saline and sacrificed 1 h after ethanol ingestion. For time course study, animals were administered ethanol 4 g/kg orally and sacrificed at 1.5, 2, 4, and 6 h after ethanol ingestion. Testicular ethanol concentration increased with increasing doses of ethanol. Copper zinc-superoxide dismutase (CuZn-SOD) activity significantly decreased in the testes of rats treated with increasing doses of ethanol whereasmanganese-superoxide dismutase (Mn-SOD) activity significantly increased in a dose dependent manner (181, 186, and 195% of control, respectively). Testicular glutathione (GSH) and malondialdehyde (MDA) levels did not significantly alter with increasing doses of ethanol one hour after ethanol ingestion. Ethanol concentration decreased in the testes with an increase in timeafter ethanol ingestion. Testicular CuZn-SOD activity significantly decreased whereas Mn-SOD activity increased with an increase in time after ethanol ingestion. Testicular catalase (CAT) activity significantly decreased at 2 h postethanol ingestion. Testicular MDA levels significantly increased at4 and 6 h after ethanol ingestion indicating that end product of lipid peroxidation, MDA, takes considerable time to form in the testes. A significant decrease in the ratios of CAT/Mn-SOD and glutathione peroxidase (GSH-Px)/Mn-SOD in the testes of rat suggests the ability of mitochondria to scavenge reactive oxygen species (ROS). It is suggested that antioxidant enzyme ratios may be used as an important parameter to determine ethanol induced oxidative stress in the tissues. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 05:41:34