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Titolo:
Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice
Autore:
Jamensky, NT; Gianoulakis, C;
Indirizzi:
McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ, Douglas Hosp, Res Ctr, Dept Physiol, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Physiol, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
ALCOHOL
fascicolo: 2-3, volume: 18, anno: 1999,
pagine: 177 - 187
SICI:
0741-8329(199906/07)18:2-3<177:COTPAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC BETA-ENDORPHIN; RECEPTOR MESSENGER-RNA; NUCLEUS-ACCUMBENS; ETHANOL-CONSUMPTION; DOPAMINE RELEASE; ENDOGENOUS OPIOIDS; RHESUS-MONKEYS; DELTA-RECEPTOR; MU-OPIATE; ANA RATS;
Keywords:
proenkephalin mRNA; enkephalin peptides; proopiomelanocortin mRNA; beta-endorphin peptides; alcohol-preferring mice; alcohol-avoiding mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Gianoulakis, C McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 nada
Citazione:
N.T. Jamensky e C. Gianoulakis, "Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice", ALCOHOL, 18(2-3), 1999, pp. 177-187

Abstract

Differences in the activity of distinct components of the endogenous opioid system between ethanol-preferring and ethanol-avoiding animals may be important in controlling their voluntary alcohol consumption. The objective ofthe present studies was to compare the activity of two opioid peptide systems (enkephalin and beta-endorphin) in distinct regions of the brain, between the C57BL/6 and DBA/2 mice, using sensitive radioimmunoassays, in situ hybridization, and immunohistochemical techniques. The immunohistochemical studies indicated that there was no significant difference in the number of either beta-endorphin or enkephalin immunopositive cells between the C57BL/6 and DBA/2 mice. The in situ hybridization studies demonstrated a 27% higher content of proopiomelanocortin mRNA in the arcuate nucleus of the C57BL/6 than DBA/2 mice, p < 0.02. The content of proenkephalin mRNA was 25% higher in the nucleus accumbens, p < 0.005 and 23% higher in the caudate putamen, p < 0.01, of the C57BL/6 than DBA/2 mice. There was no significant difference in the content of beta-endorphin peptides in the distinct brain regions investigated. The content of met-enkephalin-arg(6)-phe(7) in the nucleusaccumbens and caudate was similar between the two strains of mice, while it was significantly lower in the amygdala, hippocampus, ventral tegmental area, and periaqueductal grey of the C57BL/6 than DBA/2 mice. Thus, there are significant differences in the activity of these two endogenous opioid peptide systems in distinct regions of the brain, between ethanol naive C57BL/6 and DBA/2 mice, which may play a role in controlling their alcohol consumption. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:56:21