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Titolo:
The central melanocortin system and energy homeostasis
Autore:
Cone, RD;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 6, volume: 10, anno: 1999,
pagine: 211 - 216
SICI:
1043-2760(199908)10:6<211:TCMSAE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROOPIOMELANOCORTIN MESSENGER-RNA; AGOUTI OBESITY SYNDROME; EARLY-ONSET OBESITY; NEUROPEPTIDE-Y; FRAMESHIFT MUTATION; GENE-EXPRESSION; ARCUATE NUCLEUS; FOOD-INTAKE; OB/OB MICE; LEPTIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Cone, RD Oregon Hlth Sci Univ, Vollum Inst, 3181 SW Sam Jackson Pk Rd, Portland, OR97201 USA Oregon Hlth Sci Univ 3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
R.D. Cone, "The central melanocortin system and energy homeostasis", TRENDS ENDO, 10(6), 1999, pp. 211-216

Abstract

Obesity is a significant health problem owing to increased risk for diabetes and cardiovascular disease, and several lines of evidence suggest that alterations in the central melanocortin system might account for some of thegenetic contribution to obesity in humans. First, the phenotypic aspects and dominant inheritance of; the;w melanocortin obesity syndromes in the mouse are more like human obesity than other murine obesity syndromes. Second studies recently published present two rare cases of familial obesity resulting from null alleles of the proopiomelanocortin (POMC) gene, providing the first evidence that the melanocortin pathway in humans subserves the samefunction in regulation of energy homeostasis as it does in the rodent. Additional studies suggest that heterozygous mutations in the melanocortin 4- receptor might be a common reason for generic predisposition to obesity in children. Research on the central melanocortin system in rodents suggests that this system might be a fundamental component of the adipostat, the mechanism by which energy stoves ave held relatively constant, and this hypothesis will be the focus of this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:14:32