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Titolo:
Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
Autore:
Cohen, RM; Carson, RE; Wyatt, RJ; Doudet, DJ;
Indirizzi:
NIH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIH, PET Dept, Ctr Clin, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, PET Dept, Ctr Clin, Bethesda, MD 20892 USA NIMH, Neuropsychiat Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 , Neuropsychiat Branch, Bethesda, MD 20892 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 33, anno: 1999,
pagine: 282 - 288
SICI:
0887-4476(19990915)33:4<282:ORAIRB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE PATIENTS; ENKEPHALIN GENE-EXPRESSION; DOPA-INDUCED DYSKINESIAS; EXCITATORY AMINO-ACID; RAT SUBSTANTIA-NIGRA; MESSENGER-RNA LEVELS; BASAL GANGLIA; MET-ENKEPHALIN; PRIMATE MODEL; HUMAN-BRAIN;
Keywords:
Parkinson's disease; neurodegeneration; positron emission tomography; basal ganglia; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, RM NIH, Cerebral Metab Lab, Bldg 36,Room 1A05,36 Convent Dr,MSC 4030, Bethesda, MD 20892 USA NIH Bldg 36,Room 1A05,36 Convent Dr,MSC 4030 Bethesda MD USA 20892
Citazione:
R.M. Cohen et al., "Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP", SYNAPSE, 33(4), 1999, pp. 282-288

Abstract

Opiate receptor avidity (unoccupied receptor density / the receptor dissociation constant), was measured in four animals with unilateral parkinsoniansymptoms following MPTP ( 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) infusions into the internal carotid of one side, and nine normal controls with positron emission tomography (PET) and 6-deoxy-6-beta-[F-18] fluoronaltrexone (cyclofoxy, CF), a mu- and kappa-opiate receptor antagonist. PET studies of 6-[F-18] -L-fluoro-L-3,4-dihydroxyphenylalanine ([F-18]-DOPA) in these parkinsonian animals, although documenting the primarily unilateral nature of the lesion, also demonstrated a milder loss of dopaminergic on the side opposite the infusion. Opiate receptor avidity was found to be reduced by20-34% in the caudate, anterior putamen, thalamus, and amygdala of these primarily unilaterally MPTP-exposed animals, bilaterally with no statistically significant differences between the two sides. The affected regions are the same as those previously demonstrated to have a 30-35% loss in clinically recovered bilaterally MPTP-lesioned animals. These findings confirm thatthe opiate pathway can change in response to modest decreases in basal ganglia dopamine innervation. Thus, opiate pathway adaptation is likely to contribute to the dynamic changes in basal ganglia circuits that forestall theinitial clinical manifestations of Parkinson's disease. In addition, opiate pathway(s) may contribute to the treatment responsiveness and progressionof the disease either directly through effects on basal ganglia function or indirectly through effects on basal ganglia plasticity. Synapse 33:282-288, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 30/09/20 alle ore 05:58:36