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Titolo:
Human adenoviruses: Evading detection by cytotoxic T lymphocytes
Autore:
Blair, GE; Hall, KT;
Indirizzi:
Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
SEMINARS IN VIROLOGY
fascicolo: 5, volume: 8, anno: 1998,
pagine: 387 - 397
SICI:
1044-5773(199804)8:5<387:HAEDBC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; CLASS-I ANTIGENS; HIGHLY ONCOGENIC ADENOVIRUS-12; E3 14.7-KILODALTON PROTEIN; CELL-SURFACE EXPRESSION; TRANSFORMED RAT-CELLS; CAA REPEATED ELEMENT; DOWN-REGULATION; GENE-EXPRESSION;
Keywords:
adenovirus E1A oncogene; E3-19K; E3 gene products; MHC class I molecules; TAP; LMP; oncogenic transformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Blair, GE Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT Yorkshire, England
Citazione:
G.E. Blair e K.T. Hall, "Human adenoviruses: Evading detection by cytotoxic T lymphocytes", SEMIN VIROL, 8(5), 1998, pp. 387-397

Abstract

Human adenoviruses cause lytic and persistent respiratory, enteric, and other infections. Adenoviruses can transform primary rodent cells and certainserotypes of human adenoviruses (such as adenovirus type 12 from subgenus A) induce tumors in newborn rodents. In both cases, adenovirus gene products mediate evasion of the cellular immune system by infected and tumor cells. In viral infection, a product of the early region E3 gene, a glycoproteintermed E3-19K, binds to and retains newly synthesised major histocompatibility complex (MHC) class I molecules in the endoplasmic reticulum thus rendering infected cells resistant to lysis by cytotoxic T lymphocytes. In addition, other products of the E3 region confer on infected cells resistance to tumor necrosis factor-alpha-mediated lysis. Not all human adenovirus serotypes encode an E3-19K protein: viruses from subgenus A (such as adenovirus12) and F (the enteric adenoviruses 40 and 41) do not encode an E3-19K molecule. In the case of Ad12, products of the viral EIA gene repress MHC class I heavy chain gene transcription. This leads to loss of MHC class I molecules from the surface of adenovirus 12-transformed cells and contributes totheir evasion from cytotoxic T lymphocytes. Considerable progress has beenmade toward identifying the targets for E1A-mediated repression of the class I heavy chain promoter In addition, adenovirus 12 mediates transcriptional repression of other genes in the MHC complex involved in antigen presentation, namely the transporter associated with antigen presentation (TAP) genes and MHC-encoded proteasome components, the low molecular weight proteins termed LMPs. Overall, adenoviruses display a variety of differing mechanisms for posttranslational (E3-19K) and transcriptional (E1A) repression of MHC class I expression that operate in all human viral serotypes studied, suggesting that evasion of cytotoxic T cell lysis forms an important part ofthe infection and oncogenic transformation strategies adopted by human adenoviruses. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:19:37