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Titolo:
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
Autore:
Bauer, S; Groh, V; Wu, J; Steinle, A; Phillips, JH; Lanier, LL; Spies, T;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc Palo Alto CA USA 94304 CA 94304 USA
Titolo Testata:
SCIENCE
fascicolo: 5428, volume: 285, anno: 1999,
pagine: 727 - 729
SICI:
0036-8075(19990730)285:5428<727:AONCAT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; CLASS-I MOLECULES; INHIBITORY RECEPTOR; HLA-E; EXPRESSION; SUPERFAMILY; RECOGNITION; LYMPHOCYTES; CD94/NKG2A; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Spies, T Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave N, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N Seattle WA USA 98109
Citazione:
S. Bauer et al., "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA", SCIENCE, 285(5428), 1999, pp. 727-729

Abstract

Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gamma delta T cells, CD8(+) alpha beta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.

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Documento generato il 02/07/20 alle ore 21:16:04