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Titolo:
Dopamine and hippocampal input to the nucleus accumbens play an essential role in the search for food in an unpredictable environment
Autore:
Floresco, SB; Phillips, AG;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
PSYCHOBIOLOGY
fascicolo: 2, volume: 27, anno: 1999,
pagine: 277 - 286
SICI:
0889-6313(199906)27:2<277:DAHITT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCOMOTOR-ACTIVITY; VENTRAL STRIATUM; SPATIAL MEMORY; RAT; NEURONS; RECEPTOR; SUBICULUM; NOVELTY; REWARD; MAZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, AG Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4
Citazione:
S.B. Floresco e A.G. Phillips, "Dopamine and hippocampal input to the nucleus accumbens play an essential role in the search for food in an unpredictable environment", PSYCHOBIOLO, 27(2), 1999, pp. 277-286

Abstract

The role of D-1 and D-2 receptors in the nucleus accumbens, and their interaction with hippocampal afferents in mediating exploration, was assessed during a foraging task on a radial-arm maze. In Experiment 1, bilateral infusions into the nucleus accumbens of the D-1 antagonist SCH 23390 (50, 100, or 500 ng), but not the D-2 antagonist sulpiride (125, 250, or 500 ng), disrupted foraging for four pellets placed at random on an eight-arm radial maze. In Experiment 2, we examined the effects on foraging of blockade of dopamine receptors in the nucleus accumbens in combination with temporary disruption of information relayed by hippocampal afferents to the ventral striatum. Specifically, we employed an asymmetrical infusion procedure that consisted of a unilateral infusion of SCH 23390 (500 ng) into the nucleus accumbens in combination with a contralateral lidocaine-induced inactivation of the ventral CA1/subiculum, and this asymmetrical infusion procedure disrupted choice of unexplored arms on the radial-arm maze. These data suggest that mesoaccumbens dopamine transmission selectively modulates hippocampal inputs to the nucleus accumbens via an action at D-1 receptors when an animal is searching for food in the absence of stimuli that predict where food is located in a complex environment.

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Documento generato il 26/01/20 alle ore 16:07:50