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Titolo:
Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues
Autore:
Parkinson, JA; Robbins, TW; Everitt, BJ;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
PSYCHOBIOLOGY
fascicolo: 2, volume: 27, anno: 1999,
pagine: 256 - 266
SICI:
0889-6313(199906)27:2<256:SELOTN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; LIMBIC-STRIATAL INTERACTIONS; IBOTENIC ACID LESIONS; RAT VENTRAL STRIATUM; GENE C-FOS; DOPAMINE RELEASE; AMYGDALA; FEAR; STIMULI; INVOLVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Parkinson, JA Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB23EB, England Univ Cambridge Downing St Cambridge England CB2 3EB England
Citazione:
J.A. Parkinson et al., "Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues", PSYCHOBIOLO, 27(2), 1999, pp. 256-266

Abstract

The nucleus accumbens (NAcc) is implicated in reward-related processes andin reinforcement learning. However, its precise role in associative processes is unclear and may not be related solely to appetitive learning. In thepresent study, the differential effects of selective excitotoxic lesions of the NAcc core and shell were studied on the acquisition of an aversive Pavlovian conditioning task that assessed conditioning to both discrete and contextual cues. Rats with selective lesions of the NAcc shell were not impaired on measures of aversive Pavlovian conditioning to either discrete or contextual cues. In contrast, animals with lesions of the NAcc core showed an impairment; in conditioning to discrete cues and an enhancement in conditioning to contextual cues. The NAcc is thus implicated in aspects of aversive Pavlovian conditioning; the significance of this finding for theories ofcortico-striatal function is discussed.

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Documento generato il 03/06/20 alle ore 07:24:11