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Titolo:
Functions of the dopaminergic innervation of the nucleus accumbens
Autore:
Gray, JA; Kumari, V; Lawrence, N; Young, AMJ;
Indirizzi:
Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England Inst Psychiat, Sect Cognit Psychopharmacol, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Univ Leicester, Leicester, Leics, England Univ Leicester Leicester Leics England cester, Leicester, Leics, England
Titolo Testata:
PSYCHOBIOLOGY
fascicolo: 2, volume: 27, anno: 1999,
pagine: 225 - 235
SICI:
0889-6313(199906)27:2<225:FOTDIO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; LATENT INHIBITION; PREPULSE INHIBITION; EXTRACELLULAR DOPAMINE; CHRONIC-SCHIZOPHRENICS; CHRONIC AMPHETAMINE; SWITCHING MODEL; ANIMAL-MODEL; RAT; REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Gray, JA Inst Psychiat, Dept Psychol, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF AF, England
Citazione:
J.A. Gray et al., "Functions of the dopaminergic innervation of the nucleus accumbens", PSYCHOBIOLO, 27(2), 1999, pp. 225-235

Abstract

Two different current views hold that the mesolimbic dopaminergic projection to the nucleus accumbens mediates (1) the behavioral effects of reward or positive incentive motivation and (2) the cognitive functions that go awry in acute schizophrenia. These two views are difficult to integrate with each other. The former view fits better with the established role that the nucleus accumbens plays in the motor programming circuitry of the basal ganglia; but it fits poorly with evidence that dopamine release is provoked in the nucleus accumbens not only by rewarding, but also by aversive, stimuli. We review evidence, especially from experiments using the prepulse and latent inhibition paradigms, consistent with a role for the mesolimbic dopaminergic pathway in the cognitive dysfunctions of schizophrenia We also propose a new model for the functions of this pathway which draws on recent evidence that the nucleus accumbens has outputs to perceptual as well as motor systems. The model is able in principle to account for the data sets that support both major current views of the functions of the mesolimbic dopaminergic system. It has not yet received support, however, from direct experimental tests.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:05:24