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Titolo:
Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects
Autore:
Kadrmas, DJ; Frey, EC; Tsui, BMW;
Indirizzi:
Univ Utah, CAMT, Dept Radiol, Med Imaging Res Lab, Salt Lake City, UT 84108 USA Univ Utah Salt Lake City UT USA 84108 s Lab, Salt Lake City, UT 84108 USA Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Engn, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 adiol, Chapel Hill, NC 27599 USA
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 7, volume: 44, anno: 1999,
pagine: 1843 - 1860
SICI:
0031-9155(199907)44:7<1843:STSIWM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON EMISSION TOMOGRAPHY; SCATTER COMPENSATION; TC-99M SPECT; SPATIAL DISTRIBUTIONS; PHANTOM EVALUATION; ORDERED SUBSETS; CARDIAC PHANTOM; RECONSTRUCTION; TL-201; IMPLEMENTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kadrmas, DJ Univ Utah, CAMT, Dept Radiol, Med Imaging Res Lab, 729 ArapeenDr, Salt Lake City, UT 84108 USA Univ Utah 729 Arapeen Dr Salt Lake City UT USA 84108 84108 USA
Citazione:
D.J. Kadrmas et al., "Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects", PHYS MED BI, 44(7), 1999, pp. 1843-1860

Abstract

Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross-contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-99m-sestamibi and thallium-201, and they were compared with a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross-talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared with a NMSE of 0.091 for the subtraction-based compensation method. The application of a preliminary model for cross-talk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions wouldprobably benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dual-isotope protocols an effective alternative for many imaging procedures.

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Documento generato il 25/01/20 alle ore 04:05:21