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Titolo:
Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery
Autore:
Leseth, KH; Adner, M; Berg, HK; White, LR; Aasly, J; Edvinsson, L;
Indirizzi:
Univ Trondheim Hosp, Dept Neurol, Trondheim, Norway Univ Trondheim Hosp Trondheim Norway sp, Dept Neurol, Trondheim, Norway Univ Lund Hosp, Dept Internal Med, Div Expt Vasc Res, S-22185 Lund, SwedenUniv Lund Hosp Lund Sweden S-22185 v Expt Vasc Res, S-22185 Lund, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 10, anno: 1999,
pagine: 2355 - 2359
SICI:
0959-4965(19990802)10:11<2355:CIEERC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; SUBARACHNOID HEMORRHAGE; PLASMA ENDOTHELIN-1; ORGAN-CULTURE; B RECEPTORS; INTERLEUKIN-1; ANTAGONIST; MOLECULES; VASOSPASM; SEVERITY;
Keywords:
cerebral arteries; cytokines; endothelin receptors; interleukin-1; interleukin-2; interleukin-6; rat; sarafotoxin S6c; tumor necrosis factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Edvinsson, L Univ Trondheim Hosp, Dept Neurol, Trondheim, Norway Univ Trondheim Hosp Trondheim Norway ol, Trondheim, Norway
Citazione:
K.H. Leseth et al., "Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery", NEUROREPORT, 10(11), 1999, pp. 2355-2359

Abstract

THE plasticity of endothelin ETB receptor activity and the influence of pro-inflammatory cytokines was examined in cerebral artery. In fresh rat basilar artery, the selective ETB receptor agonist, sarafotoxin S6c, induced negligible contractions. However, after 1 day of organ culture, fully definedconcentration-response curves were obtained in artery segments exposed to sarafotoxin S6c. Organ culture in the presence of either interleukin-1 betaor tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6, further amplified the maximal contraction to sarafotoxin S6c. The plasticityof ETB recpetor expression in cerebral arteries and sensitivity for pro-inflammatory cytokines, suggest a role in inflammatory cerebral diseases suchas stroke. NeuroReport 10:2355-2359 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:20:42