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Titolo:
Temporal profile of CREB phosphorylation after focal ischemia in rat brain
Autore:
Tanaka, K; Nogawa, S; Nagata, E; Suzuki, S; Dembo, T; Kosakai, A; Fukuuchi, Y;
Indirizzi:
Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Neurol, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 10, anno: 1999,
pagine: 2245 - 2250
SICI:
0959-4965(19990802)10:11<2245:TPOCPA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY OCCLUSION; ELEMENT-BINDING PROTEIN; C-FOS; TRANSCRIPTION; EXPRESSION; KINASE; GENE; INDUCTION; FAMILY; DAMAGE;
Keywords:
cAMP response element binding protein; cerebral ischemia; CREB; middle cerebral artery; phosphorylation; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, K Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 yo 1608582, Japan
Citazione:
K. Tanaka et al., "Temporal profile of CREB phosphorylation after focal ischemia in rat brain", NEUROREPORT, 10(11), 1999, pp. 2245-2250

Abstract

THE phosphorylation of cAMP response element binding protein (CREB) in therat brain was examined immunohistochemically at 3.5 h, 12 h, 24 h and 48 hof recirculation after focal ischemia induced by occlusion of the middle cerebral artery for 1.5 h. Brain sections were stained with affinity purified anti-phosphorylated CREB antibody. The ischemic core revealed a significant, but transient increase in number of phosphorylated CREB-positive cells at 3.5 h of recirculation, followed by a rapid decrease during the subsequent period. In the peri-ischemia area, the number of phosphorylated CREB-positive cells showed a more marked increase as compared to that in the ischemic core at 3.5 h of recirculation, and the increase continued until 48 h ofrecirculation with a tendency for gradual decline. Persistent enhancement of CREB phosphorylation may thus be closely related to the neuronal viability and neuroprotective mechanisms, whereas rapid disappearance of CREB phosphorylation may clearly precede neuronal death. NeuroReport 10:2245-2250 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:03:21