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Titolo:
Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease
Autore:
Turner, PJ; Foreman, JC;
Indirizzi:
Univ Coll London, Dept Pharmacol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT macol, London WC1E 6BT, England
Titolo Testata:
MEDIATORS OF INFLAMMATION
fascicolo: 3, volume: 8, anno: 1999,
pagine: 133 - 146
SICI:
0962-9351(1999)8:3<133:HITHNA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; EOSINOPHIL CATIONIC PROTEIN; MAJOR BASIC-PROTEIN; PIG ISOLATED TRACHEA; INDUCED BRONCHIAL HYPERRESPONSIVENESS; VASOACTIVE-INTESTINAL-PEPTIDE; COLONY-STIMULATING FACTOR; NITRIC-OXIDE SYNTHESIS; GENE-RELATED PEPTIDE; SUBSTANCE-P;
Keywords:
human nasal airway; hyperresponsiveness; eosinophils; bradykinin; neuropeptides; nitric oxide;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Foreman, JC Univ Coll London, Dept Pharmacol, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT BT, England
Citazione:
P.J. Turner e J.C. Foreman, "Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease", MEDIAT INFL, 8(3), 1999, pp. 133-146

Abstract

ALLERGIC rhinitis is a condition which affects over 15% of the population in the United Kingdom. The pathological process involves two stages: nasal inflammation, and the development of nasal airway hyperresponsiveness (AHR)to allergen and a number of other stimuli. This results in the amplification of any subsequent allergic reaction, contributing to the chronic allergic state. A number of different hypotheses have been proposed to explain theunderlying mechanism of AHR, including a role for eosinophil-derived proteins, free radicals and neuropeptides. While there may be a number of independent pathways which can result in AHR, evidence obtained from both animal models and in vivo experiments in humans indicate that some mediators may interact with one another, resulting in AHR. Further research into these interactions may open new avenues for the pharmacological treatment of chronicallergic rhinitis, and possibly other allergic airway diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:27:10