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Titolo:
Genetic analysis of neonatal death with growth retardation in F-1 male Dh/plus mice
Autore:
Suto, J; Yamanaka, H; Sekikawa, K;
Indirizzi:
Natl Inst Anim Hlth, Dept Immunol, Tsukuba, Ibaraki 3050856, Japan Natl Inst Anim Hlth Tsukuba Ibaraki Japan 3050856 Ibaraki 3050856, Japan
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 8, volume: 10, anno: 1999,
pagine: 777 - 783
SICI:
0938-8990(199908)10:8<777:GAONDW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
C57BL/6J-Y-POS SEX REVERSAL; MAMMALIAN Y-CHROMOSOME; DOMINANT HEMIMELIA; INBRED STRAINS; DNA-SEQUENCE; DDD FEMALE; POLYMORPHISM; LETHALITY; ORIGIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Suto, J Natl Inst Anim Hlth, Dept Immunol, Tsukuba, Ibaraki 3050856, JapanNatl Inst Anim Hlth Tsukuba Ibaraki Japan 3050856 3050856, Japan
Citazione:
J. Suto et al., "Genetic analysis of neonatal death with growth retardation in F-1 male Dh/plus mice", MAMM GENOME, 10(8), 1999, pp. 777-783

Abstract

Nearly all F-1 male mice with Dh/+ genotype between DDD female and DH-Dh/male die within a few days after birth; however, this is not observed in the reciprocal cross. The F-1 Dh/+ males usually exhibit growth retardation prior to death. To identify the putative genetic locus or loci in DDD genome that cause the abnormalities in the presence of the Dh, a linkage analysis was carried out in backcross progeny of a cross of (DDD female x DH-+/+ male) F-1 female x DH-Dh/+ male. Appearance of growth retardation was examined from the day of birth, and both growth-retarded and normally weaned Dh/males were genotyped for microsatellite marker loci spanning autosomes andthe X Chromosome (Chr). Significant evidence for linkage was identified onthe distal edge of the X Chr, near the microsatellite marker of DXMit135. Furthermore, among mice from DDD female x reciprocal F(1)Dh/+ male producedbetween DH-Dh/+ and progenitor strains (C57BL/6J, C3H/HeJ and BALB/cA), only the progeny from female DDD x male(female DH-Dh/+ x male C3H/HeJ) F-1 Dh/+ male did not show any lethality and/or growth retardation. Thus, the lethality in F-1 Dh/+ males accompanied by growth retardation is caused by theinteractions between the Dh gene, X Chr, and Y Chr. Based on the CAG repeat sequence length polymorphism among Mus musculus musculus Sry gene, C3H/HeJ was different from C57BL/6J, BALB/cA, and DH. These data suggest that there are at least two functional types of Y Chr in Mus musculus musculus.

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Documento generato il 14/07/20 alle ore 09:51:13