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Titolo:
Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer
Autore:
Smythe, WR; Williams, JP; Wheelock, MJ; Johnson, KR; Kaiser, LR; Albelda, SM;
Indirizzi:
Univ Texas, Dept Thorac & Cardiovasc Surg, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Anderson Canc Ctr, Houston, TX 77030 USA Univ Penn, Med Ctr, Dept Surg, Thorac Surg Sect, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Surg Sect, Philadelphia, PA 19104 USA Univ Penn, Med Ctr, Dept Med, Div Pulm Crit Care, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Crit Care, Philadelphia, PA 19104 USA Univ Toledo, Dept Biol, Toledo, OH 43606 USA Univ Toledo Toledo OH USA 43606 v Toledo, Dept Biol, Toledo, OH 43606 USA
Titolo Testata:
LUNG CANCER
fascicolo: 3, volume: 24, anno: 1999,
pagine: 157 - 168
SICI:
0169-5002(199906)24:3<157:CACEIN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ESOPHAGEAL CANCER; MOLECULE E-CADHERIN; ADHESION MOLECULE; ALPHA-CATENIN; BETA-CATENIN; PROSTATE-CANCER; P-CADHERIN; IMMUNOHISTOCHEMICAL EVALUATION; PLAKOGLOBIN EXPRESSION; GASTRIC CARCINOMAS;
Keywords:
lung cancer; cell adhesion; cadherins; catenins; lung; thoracic oncology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Smythe, WR Univ Texas, Dept Thorac & Cardiovasc Surg, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 anc Ctr, Houston, TX 77030 USA
Citazione:
W.R. Smythe et al., "Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer", LUNG CANC, 24(3), 1999, pp. 157-168

Abstract

Cadherins are transmembrane cell adhesion molecules (CAMS) that mediate cell-cell interactions and are important for maintenance of epithelial cell integrity. This function is dependent on an indirect interaction between thecytoplasmic domain of the cadherin molecule with three cytoplasmic proteins known as alpha-, beta-, and gamma-catenin (-cat). Growing evidence suggests that alterations in cadherin or catenin expression or function may be important to the development of an invasive or metastatic phenotype. Immunohistochemical techniques were used to study the expression of the two major epithelial cadherins, E-cadherin (E-cad) and P-cadherin (P-cad) as well as alpha- and gamma-cat in normal bronchial epithelium and in a series of carefully TMN-staged pulmonary adenocarcinomas (n = 21) and squamous cell carcinomas (n = 7). The cadherin profile of normal pseudostratified bronchial epithelium was heterogeneous. Basilar cells strongly expressed P-cad, alpha- and gamma-cat, while columnar cells moderately expressed E-cad, alpha- and gamma-cat. In contrast to other epithelial tumors, E-cad on non-small cell lung carcinomas was actually upregulated, however, a decrease in P-cad expression was noted in 68%. At least one cadherin or catenin was downregulated,compared to normal bronchial epithelium, in 82% of tumors examined. With the exception of an association between loss of P-cad expression and poorly differentiated state, changes in cadherin and catenin expression levels were not significantly correlated to tumor stage, cell type, or nodal status. These findings illustrate that alteration of expression of cadherins and catenins are often found in non-small cell lung carcinoma when compared to the progenitor bronchial epithelium, and may play a role in the development of the malignant phenotype. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:55:02