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Titolo:
Long-term outcome in children after antenatal intervention for obstructiveuropathies
Autore:
Freedman, AL; Johnson, MP; Smith, CA; Gonzalez, R; Evans, MI;
Indirizzi:
Childrens Hosp Michigan, Dept Paediat Urol, Detroit, MI 48201 USA Childrens Hosp Michigan Detroit MI USA 48201 Urol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Hutzel Hosp, Dept Obstet & Gynaecol, Detroit, MI USA Wayne State Univ Detroit MI USA Dept Obstet & Gynaecol, Detroit, MI USA Wayne State Univ, Sch Med, Hutzel Hosp, Dept Mol Med & Geriatr, Detroit, MI USA Wayne State Univ Detroit MI USA Dept Mol Med & Geriatr, Detroit, MI USA Wayne State Univ, Sch Med, Hutzel Hosp, Dept Pathol, Detroit, MI USA WayneState Univ Detroit MI USA utzel Hosp, Dept Pathol, Detroit, MI USA
Titolo Testata:
LANCET
fascicolo: 9176, volume: 354, anno: 1999,
pagine: 374 - 377
SICI:
0140-6736(19990731)354:9176<374:LOICAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR URETHRAL VALVES; CONGENITAL HYDRONEPHROSIS INUTERO; FETAL RENAL-FUNCTION; PRUNE BELLY SYNDROME; PULMONARY HYPOPLASIA; GROWTH; BLADDER; OLIGOHYDRAMNIOS; BIOCHEMISTRY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Freedman, AL 100 UCLA Med Plaza,Suite 690, Los Angeles, CA 90095 USA 100 UCLA Med Plaza,Suite 690 Los Angeles CA USA 90095 95 USA
Citazione:
A.L. Freedman et al., "Long-term outcome in children after antenatal intervention for obstructiveuropathies", LANCET, 354(9176), 1999, pp. 374-377

Abstract

Background Antenatal intervention has been done for fetal obstructive uropathy far over a decade, yet little is known about long-term outcomes. To assess the long-term implications of fetal intervention, we reviewed the outcomes of children who underwent vesicoamniotic shunt placement. Methods We reviewed the clinical outcomes of 14 children who underwent vesicoamniotic shunt placement at our institution and who survived beyond 2 years of age. Findings In 1987-96, 34 patients underwent vesicoamniotic shunt placement.13 died and 21 survived, of whom 17 are now more than 2 years old. Three survivors were lost to follow-up. Mean age at follow-up was 54.3 months (range 25-114). Final diagnoses included prune belly syndrome (seven cases), posterior urethral valves (four), urethral atresia (one), vesicoureteral reflux (one), and megacystis (one). Height was below the 25th percentile in 12 (86%) with seven (50%) below the 5th percentile. Five (36%) had renal failure and had successful transplantation, three (21%) have renal insufficiency, and six (43%) have normal renal function. Seven (50%) are acceptably continent, five (36%) have not yet begun toilet-training, and two (14%) are incontinent. Three of four children with valves needed bladder augmentation. Interpretation Antenatal intervention may help those fetuses with the mostsevere forms of obstructive uropathy, usually associated with a fatal neonatal course. intervention achieves outcomes similar to less severe cases that are usually diagnosed postnatally.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:05:11