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Titolo:
Antibody reactive with Porphyromonas gingivalis serotypes K1-6 in adult and generalized early-onset periodontitis
Autore:
Califano, JV; Schifferle, RE; Gunsolley, JC; Best, AM; Schenkein, HA; Tew, JG;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Sch Dent, Clin Res Ctr Periodontal Dis, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VAUSA 23298 , Richmond, VA 23298 USA SUNY Buffalo, Dept Periodontol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Dept Periodontol, Buffalo, NY 14260 USA SUNY Buffalo, Dept Oral Biol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 , Dept Oral Biol, Buffalo, NY 14260 USA
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 7, volume: 70, anno: 1999,
pagine: 730 - 735
SICI:
0022-3492(199907)70:7<730:ARWPGS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPIDLY PROGRESSIVE PERIODONTITIS; G SUBCLASS CONCENTRATIONS; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; IMMUNODOMINANT ANTIGENS; JUVENILE PERIODONTITIS; BACTEROIDES-GINGIVALIS; CAPSULAR SEROTYPES; YOUNG-ADULTS; SMOKING; LIPOPOLYSACCHARIDE;
Keywords:
antibodies; antigens, K; IgG; periodontitis; serotype; Porphyromonas gingivalis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Califano, JV Virginia Commonwealth Univ, Med Coll Virginia, Sch Dent, ClinRes Ctr Periodontal Dis, Wood Mem Bldg,Room 401,521 N 11th St, Richmond, VA 23298 USA Virginia Commonwealth Univ Wood Mem Bldg,Room 401,521 N 11th StRichmond VA USA 23298
Citazione:
J.V. Califano et al., "Antibody reactive with Porphyromonas gingivalis serotypes K1-6 in adult and generalized early-onset periodontitis", J PERIODONT, 70(7), 1999, pp. 730-735

Abstract

Background: Six serotypes of Porphyromonas gingivalis have recently been described. We sought to test the hypothesis that serotype specific carbohydrates from these strains are important antigens that elicit potent: immune responses. Methods: Serum concentrations of IgG reactive with P gingivalis serotypes K1-K6 were determined for 28 adult (AP) and 28 generalized early-onset (G-EOP) periodontitis patients previously determined to be seropositive for a broken cell preparation of P. gingivalis. To confirm relationships suggestedfor KI, K2, and K6 in the analysis of initial data, the study population was increased to 133. Results: Frequency of seropositivity for;the 6 serotypes ranged from 26 to54% of subjects. IgG concentrations ranged from 0 to 453 mu g/ml with manysubjects seropositive to more than one serotype. Concentrations for the subset of patients who was seropositive were high (mean responses ranged from20 to 105 mu g/ml for the 6 serotypes). Significant correlations between seropositivity to serotypes K1 and K5 as well as between K5 and K6 were found. Conclusions: We examined the relationship of diagnosis, race, gender, smoking, probing depth, attachment loss, and antibody reaction with the P gingivalis serotypes by analysis of variance. Initial findings suggested potential relationships between diagnosis, smoking, race, gender, and antibody reactive with serotypes K1, K2, and K6. A significant relationship did exist between smoking and decreased antibody reactive with Pi gingivalis serotype K2. No other relationships were substantiated. We also examined the Ige subclass distribution and found that responses were almost exclusively IgG2. These data support the concept that antibody responses to all 6 serotypes are common in both AP and G-EOP and that these K serotype carbohydrates elicit potent IgG2 responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:14:53