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Titolo:
Excitotoxic septal lesions result in spatial memory deficits and altered flexibility of hippocampal single-unit representations
Autore:
Leutgeb, S; Mizumori, SJY;
Indirizzi:
Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA Univ Utah Salt LakeCity UT USA 84112 ychol, Salt Lake City, UT 84112 USA Univ Utah, Program Neurosci, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 rosci, Salt Lake City, UT 84112 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 15, volume: 19, anno: 1999,
pagine: 6661 - 6672
SICI:
0270-6474(19990801)19:15<6661:ESLRIS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY-MOVING RAT; NUCLEUS BASALIS MAGNOCELLULARIS; COMPLEX-SPIKE CELLS; AGE-RELATED-CHANGES; WORKING-MEMORY; MEDIAL SEPTUM; THETA-RHYTHM; SELECTIVE IMMUNOLESIONS; IMMUNOREACTIVE CELLS; CONTAINING NEURONS;
Keywords:
medial and lateral septum; hippocampus; place cells; spatial working memory; aging; acetylcholine; GABA projection neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Mizumori, SJY Univ Utah, Dept Psychol, 390 S 1530 E,Room 502, Salt Lake City, UT 84112 USA Univ Utah 390 S 1530 E,Room 502 Salt Lake City UT USA 84112
Citazione:
S. Leutgeb e S.J.Y. Mizumori, "Excitotoxic septal lesions result in spatial memory deficits and altered flexibility of hippocampal single-unit representations", J NEUROSC, 19(15), 1999, pp. 6661-6672

Abstract

The septal nuclei are reciprocally connected with the hippocampal formation and contribute importantly to spatial and memory processing. Using excitotoxic lesions of the septal area, we investigated whether neurodegenerationin subcortical projections to hippocampus can compromise flexible information processing by hippocampal single units. In agreement with the mild effects of excitotoxic septal lesions on hippocampal physiology compared with fimbria-fornix lesions and septal inactivation, we observed limited lesion effects on single-unit activity. The location specificity of hippocampal complex spike cells remained unchanged, but a less reliable location-dependentdischarge was observed in experimental animals with a pronounced postoperative working memory deficit. Testing in the absence of ambient illuminationand in a new environment revealed that the spatial correlates of complex spike cells in lesioned animals may rely on a more limited set of sensory cues. Altered sensory cues resulted in a significantly different response pattern between the control and lesion group in the new environment, a situation that normally results in place field reorganization. Such a group difference was not observed during dark testing, a condition in which place fieldreorganization is less prominent. A contribution of hippocampal interneurons to the observed alterations in the spatial properties of the principal cells was suggested by decreased theta modulation in the lesioned group. Because excitotoxic lesions result in memory deficits that resemble age-related memory problems in the absence of age-related degenerative processes, we suggest that septal neurodegeneration could directly contribute to those behavioral changes with advanced age that correlate with functional alterations in the hippocampal formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 22:00:57