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Titolo:
Mitochondrial medicine - recent advances
Autore:
Graff, C; Clayton, DA; Larsson, NG;
Indirizzi:
Karolinska Hosp, Ctr Mol Med, Dept Mol Med, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Med, S-17176 Stockholm, Sweden Howard Hughes Med Inst, Chevy Chase, MD USA Howard Hughes Med Inst Chevy Chase MD USA Med Inst, Chevy Chase, MD USA
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 1, volume: 246, anno: 1999,
pagine: 11 - 23
SICI:
0954-6820(199907)246:1<11:MM-RA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; HEREDITARY OPTIC NEUROPATHY; KEARNS-SAYRE SYNDROME; RESPIRATORY-CHAIN DEFICIENCY; MANGANESE SUPEROXIDE-DISMUTASE; TRANSCRIPTION FACTOR-A; COMPLEX-I DEFICIENCY; PARKINSONS-DISEASE; DIABETES-MELLITUS; DNA DELETIONS;
Keywords:
ageing; diabetes mellitus; genetics; mitochondrial diseases; neurodegenerative diseases; radical oxygen species;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Larsson, NG Karolinska Hosp, Ctr Mol Med, Dept Mol Med, CMM L8-02, S-17176Stockholm, Sweden Karolinska Hosp CMM L8-02 Stockholm Sweden S-17176 lm, Sweden
Citazione:
C. Graff et al., "Mitochondrial medicine - recent advances", J INTERN M, 246(1), 1999, pp. 11-23

Abstract

Mitochondria contain the respiratory chain enzyme complexes that carry outoxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Mitochondrial DNA (mtDNA) encodes essential subunits of the respiratory chain and is thus critical for maintaining cellular energy production. The first pathogenic mtDNA mutations were reported in 1988, and today more than 50 disease-causing mtDNA mutations have been identified. In addition, mtDNA mutations have been implicated in ageing and in common disorders such as diabetes mellitus, heart failure and Parkinson's disease, This review will summarize recent advances in the rapidly expanding field of mitochondrial medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 18:48:57