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Titolo:
An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival
Autore:
Gorczynski, RM; Cattral, MS; Chen, ZG; Hu, JA; Lei, J; Min, WP; Yu, G; Ni, J;
Indirizzi:
Toronto Gen Hosp, Transplant Res Div, Toronto, ON M5G 2C4, Canada Toronto Gen Hosp Toronto ON Canada M5G 2C4 v, Toronto, ON M5G 2C4, Canada
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 163, anno: 1999,
pagine: 1654 - 1660
SICI:
0022-1767(19990801)163:3<1654:AIITMO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL VENOUS IMMUNIZATION; GRAFT PROLONGATION; DENDRITIC CELLS; INTERLEUKIN-12; COMBINATION; LYMPHOCYTES; EXPRESSION; TOLERANCE; SIGNALS; B7-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gorczynski, RM Toronto Gen Hosp, Transplant Res Div, CCRW 2-855,200 Elizabeth St, Toronto, ON M5G 2C4, Canada Toronto Gen Hosp CCRW 2-855,200 Elizabeth St Toronto ON Canada M5G 2C4
Citazione:
R.M. Gorczynski et al., "An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival", J IMMUNOL, 163(3), 1999, pp. 1654-1660

Abstract

We have established that, in mice receiving donor-specific immunization bythe portal vein, the increased graft survival seen is associated with the increased expression of a molecule (OX-2) on a subpopulation of dendritic cells (DC), and polarization of cytokine production to type 2 cytokines on Ag-specific restimulation of cells from these mice, Furthermore, infusion ofa mAb to OX-2 blocks both the increased graft survival and the altered cytokine production seen, We have constructed an Immunoadhesin in which the extracellular domain of OX-2 is linked to the murine IgG2a Fc region, and we have expressed this molecule (OX-2:Fc) in a eukaryotic (baculovirus) expression system. Incubation of lymphocytes with 50 ng/ml OX-2:Fc inhibits a primary mixed lymphocyte reaction in vitro, as assayed by proliferation and induction of cytotoxic T cells, and also alters cytokine production with decreased IL-2 (IFN-gamma) production and increased IL-4 (IL-10) production. Similarly, in vivo infusion of OX-2:Fc promotes increased allo- and xenograft(both skin and renal grafts) survival and decreases the Ab response to sheep erythrocytes, Our data suggest this molecule might have clinical importance in allo- and xenotransplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:45:52