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Titolo:
Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology
Autore:
Roth, KA; Kapadia, SB; Martin, SM; Lorenz, RG;
Indirizzi:
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pathol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 d, Dept Med, St Louis, MO 63110 USA Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Ctr Immunol, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 163, anno: 1999,
pagine: 1490 - 1497
SICI:
0022-1767(19990801)163:3<1490:CIRAEF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYLORI-ASSOCIATED GASTRITIS; VACUOLATING CYTOTOXIN; EPITHELIAL-CELLS; TRANSGENIC MICE; MUTANT MICE; INFECTION; MUCOSA; MOUSE; CANCER; ULCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenz, RG Washington Univ, Sch Med, Dept Pathol, Box 8118,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Box 8118,660 S Euclid Ave St Louis MO USA 63110
Citazione:
K.A. Roth et al., "Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology", J IMMUNOL, 163(3), 1999, pp. 1490-1497

Abstract

The bacteria Helicobacter pylori is a major human pathogen that infects over half of the world's population. Infection initiates a series of changes in the gastric mucosa, beginning with atrophic gastritis and leading in some patients to peptic ulcer disease, mucosa-associated lymphomas, and gastric adenocarcinoma, Although this cascade of events clearly occurs, little isknown about the role of the host immune response in disease progression, We have utilized the C57BL/6 Helicobacter felis mouse model to critically analyze the role of the adaptive immune response in the development of Helicobacter-associated gastric pathology. Infection of B and T cell deficient RAG-1(-/-) mice Or T cell-deficient TCR beta delta(-/-) mice with H, felis resulted in high levels of colonization, but no detectable gastric pathology. Conversely, infection of B cell-deficient mu MT mice resulted in severe gastric alterations identical with those seen in immunocompetent C57BL/6-infected mice, including gastric mucosal hyperplasia and intestinal metaplasia,These results demonstrate that the host T cell response is a critical mediator of Helicobacter-associated gastric pathology, and that B cells and their secreted Abs are not the effecters of the immune-mediated gastric pathology seen after H, felis infection. These results indicate that in addition to specific Helicobacter virulence factors, the host immune response is an important determinant of Helicobacter-associated disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:46:59