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Titolo:
Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles
Autore:
Martinez-Lorenzo, MJ; Anel, A; Gamen, S; Monleon, I; Lasierra, P; Larrad, L; Pineiro, A; Alava, MA; Naval, J;
Indirizzi:
Univ Zaragoza, Fac Ciencias, Dept Bioquim & Biol Mol & Celular, E-50009 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50009 & Celular, E-50009 Zaragoza, Spain Univ Zaragoza, Hosp Clin Univ, Serv Inmunol, E-50009 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50009 rv Inmunol, E-50009 Zaragoza, Spain
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 163, anno: 1999,
pagine: 1274 - 1281
SICI:
0022-1767(19990801)163:3<1274:AHTCRB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INDUCED DEATH; SOLUBLE FORM; PROTHROMBINASE ACTIVITY; SECRETORY LYSOSOMES; INDUCED APOPTOSIS; IMMUNE-RESPONSES; PLASMA-MEMBRANE; DOWN-REGULATION; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Anel, A Univ Zaragoza, Fac Ciencias, Dept Bioquim & Biol Mol & Celular, E-50009 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50009 ar, E-50009 Zaragoza, Spain
Citazione:
M.J. Martinez-Lorenzo et al., "Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles", J IMMUNOL, 163(3), 1999, pp. 1274-1281

Abstract

Activation-induced cell death is a process by which overactivated T cells are eliminated, thus preventing potential autoimmune attacks. Two known mediators of activation-induced cell death are Fas(CD95) ligand (FasL) and APO2 ligand (APO2L)/TNF-related apoptosis-inducing ligand (TRAIL), We show here that upon mitogenic stimulation, bioactive Fast and APO2L are released from the T cell leukemia Jurkat and from normal human T cell blasts as intact, nonproteolyzed proteins associated with a particulate, ultracentrifugablefraction. We have characterized this fraction as microvesicles of 100-200 nm in diameter. These microvesicles are released from Jurkat and T cell blasts shortly (less than or equal to 1 h) after PHA stimulation, well before the cell enters apoptosis, FasL- and APO2L-containing vesicles are also present in supernatants from PHA-activated fresh human PBMC, These observations provide the basis for a new and efficient mechanism for the rapid induction of autocrine or paracrine cell death during immune regulation.

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Documento generato il 26/09/20 alle ore 04:19:37