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Titolo:
Repeated oral dosing with Listeria monocytogenes in mice as a model of central nervous system listeriosis in man
Autore:
Altimira, J; Prats, N; Lopez, S; Domingo, M; Briones, V; Dominguez, L; Marco, A;
Indirizzi:
Univ Autonoma Barcelona, Fac Vet, Dept Patol & Prod Anim, Bellaterra 08193, Spain Univ Autonoma Barcelona Bellaterra Spain 08193 , Bellaterra 08193, Spain Univ Complutense Madrid, Fac Vet, Dept Patol Anim 1, E-28040 Madrid, SpainUniv Complutense Madrid Madrid Spain E-28040 im 1, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF COMPARATIVE PATHOLOGY
fascicolo: 2, volume: 121, anno: 1999,
pagine: 117 - 125
SICI:
0021-9975(199908)121:2<117:RODWLM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENINGITIS; RHOMBENCEPHALITIS; INFECTION; ENCEPHALITIS; PATHOGENESIS; OUTBREAK; FOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Marco, A Univ Autonoma Barcelona, Fac Vet, Dept Patol & Prod Anim, Bellaterra 08193, Spain Univ Autonoma Barcelona Bellaterra Spain 08193 rra 08193, Spain
Citazione:
J. Altimira et al., "Repeated oral dosing with Listeria monocytogenes in mice as a model of central nervous system listeriosis in man", J COMP PATH, 121(2), 1999, pp. 117-125

Abstract

Human listeriosis is a food-borne disease of immunosuppressed or previously healthy adults. The repeated oral administration of a sublethal dose (5 x10(9) colony-forming units) of Listeria monocytogenes for 7 or 10 consecutive days led to the development of severe central nervous system (CNS) lesions in 25% of experimental mice. Histopathological examination of the brainrevealed rhombencephalitis and ventriculitis as two distinct inflammatory patterns, resembling those seen in human listeriosis. This model would seemto be potentially useful for research on pathogenesis: predisposing factors and therapy in CNS listeriosis in man. (C) 1999 W.B. Saunders Company Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 02:17:43