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Titolo:
Incidence and predictors of drug-induced parkinsonism in older psychiatricpatients treated with very low doses of neuroleptics
Autore:
Caligiuri, MP; Lacro, JP; Jeste, DV;
Indirizzi:
Univ Calif San Diego, Movement Disorders Lab, Dept Psychiat 0603, La Jolla, CA 92053 USA Univ Calif San Diego La Jolla CA USA 92053 t 0603, La Jolla, CA 92053 USA VA San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA VA San Diego Healthcare Syst San Diego CA USA at Serv, San Diego, CA USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 322 - 328
SICI:
0271-0749(199908)19:4<322:IAPODP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRAPYRAMIDAL SYMPTOMS; SCHIZOPHRENIC-PATIENTS; ALZHEIMERS-DISEASE; ELDERLY PATIENTS; DYSKINESIA; DEMENTIA; DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Caligiuri, MP Univ Calif San Diego, Movement Disorders Lab, Dept Psychiat 0603, La Jolla, CA 92053 USA Univ Calif San Diego La Jolla CA USA 92053 la, CA 92053 USA
Citazione:
M.P. Caligiuri et al., "Incidence and predictors of drug-induced parkinsonism in older psychiatricpatients treated with very low doses of neuroleptics", J CL PSYCH, 19(4), 1999, pp. 322-328

Abstract

The available literature suggests that a sizable proportion of patients placed on neuroleptics develop acute and subacute extrapyramidal side effects, including neuroleptic-induced parkinsonism (NIP). The presence of mild, spontaneous extrapyramidal signs in the elderly makes it difficult to accurately estimate the incidence of NIP in this subgroup of patients. We examined the incidence of NIP in 56 older, newly medicated, psychiatric patients. Fifteen age-comparable, unmedicated psychiatric patients underwent 2 assessments to estimate natural fluctuation in extrapyramidal signs, and 49 normal, healthy, elderly individuals were also studied to establish age-comparable norms for the assessment of parkinsonism. Potential pretreatment predictor variables included instrumental measures of motor function, age, cognitive status, and psychiatric diagnosis. After controlling for spontaneous parkinsonism, 32% of patients met strict criteria for NIP after receiving an average of 43 mg/day chlorpromazine equivalents of a typical neuroleptic, Factors contributing to the development of NIP included older age, instrumentally derived tremor, baseline extrapyramidal signs, type of neuroleptic, and severity of dementia, The use of risperidone in a small sub-sample was not associated with; NIP. These findings indicate that even after controllingfor spontaneous extrapyramidal signs at baseline and their natural fluctuations, there is a substantial risk of NIP in older patients who are treatedwith very low doses of typical neuroleptics.

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Documento generato il 23/01/20 alle ore 06:18:16