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Titolo:
Age- and gender-related differences in vertebral bone mass, density, and strength
Autore:
Ebbesen, EN; Thomsen, JS; Beck-Nielsen, H; Nepper-Rasmussen, HJ; Mosekilde, L;
Indirizzi:
Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C , Dept Cell Biol, DK-8000 Aarhus C, Denmark Odense Univ Hosp, Dept Endocrinol, Odense, Denmark Odense Univ Hosp Odense Denmark Hosp, Dept Endocrinol, Odense, Denmark Odense Univ Hosp, Dept Radiol, Odense, Denmark Odense Univ Hosp Odense Denmark Univ Hosp, Dept Radiol, Odense, Denmark
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 8, volume: 14, anno: 1999,
pagine: 1394 - 1403
SICI:
0884-0431(199908)14:8<1394:AAGDIV>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; X-RAY ABSORPTIOMETRY; TRABECULAR BONE; BIOMECHANICAL COMPETENCE; NORMAL INDIVIDUALS; MINERAL DENSITY; SEX-DIFFERENCES; BODY SIZE; FRACTURE; SINGLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ebbesen, EN Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C Biol, DK-8000 Aarhus C, Denmark
Citazione:
E.N. Ebbesen et al., "Age- and gender-related differences in vertebral bone mass, density, and strength", J BONE MIN, 14(8), 1999, pp. 1394-1403

Abstract

This study was designed to evaluate age- and gender-related differences invertebral bone mass, density, and strength by dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), peripheral QCT (pQCT), ash measurements, and biomechanical testing, The material comprised human lumbar vertebral bodies (L3) from 51 females and 50 males (age-range: 18-96 years). The results showed that females had significantly lower vertebral body bone mass (ash weight) than males at any given age, The decline in bonemass with age was parallel for females and males, The different bone density measurements-cancellous ash density, total vertebral body ash density, DXA bone mineral density, QCT, and pQCT-showed no gender-related difference concerning numeric value or changes with age. Morphometrical measurements showed that females had smaller vertebral bodies (volumes) than males, Hencethe females had significantly smaller cross-sectional area (CSA) of L3 than males (11.6 cm(2) and 14.4 cm(2), respectively), This led to females having lower maximum compressive load (N) than males at all ages, whereas maximum compressive stress (load/CSA) showed no gender-related difference. In conclusion, females have lower vertebral body bone mass than males at any given age, due to smaller vertebral bodies. Hence, maximum compressive load (strength not corrected for size) was lower in females. Vertebral body cancellous bone density and total-vertebral body density were equal when comparing genders, and no gender differences were found in the size-corrected strength: maximum compressive stress, The decrease with age in vertebral body compressive strength decrease was twice as large as the age decrease in density.

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Documento generato il 30/11/20 alle ore 16:53:48