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Titolo:
Response of the olfactory bulb antioxidant system following diethyldithiocarbamate (DDTC) administration in rats
Autore:
Struble, RG; Husain, K; Somani, SM;
Indirizzi:
So Illinois Univ, Sch Med, Ctr Alzheimers Dis & Related Disorders, Dept Neurol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 urol, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Psychiat, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 hiat, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Pathol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 thol, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA
Titolo Testata:
JOURNAL OF APPLIED TOXICOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 221 - 228
SICI:
0260-437X(199907/08)19:4<221:ROTOBA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC SUPEROXIDE DISMUTASES; ALZHEIMERS-DISEASE; DIFFERENTIAL REGULATION; GLUTATHIONE-REDUCTASE; FREE-RADICALS; COPPER; MANGANESE; PROTEIN; BRAIN; ASSAY;
Keywords:
reactive oxygen species; olfactory bulb; antioxidant system; brain; free radicals; diethyldithiocarbamate; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Struble, RG So Illinois Univ, Sch Med, Ctr Alzheimers Dis & Related Disorders, Dept Neurol, POB 19628, Springfield, IL 62794 USA So Illinois Univ POB19628 Springfield IL USA 62794 62794 USA
Citazione:
R.G. Struble et al., "Response of the olfactory bulb antioxidant system following diethyldithiocarbamate (DDTC) administration in rats", J APPL TOX, 19(4), 1999, pp. 221-228

Abstract

This study was designed in order to evaluate alterations in the reactive oxygen species (ROS) scavenging system in olfactory bulb, dorsal neocortex and cerebellum for 6 weeks following a single subcutaneous dose (600 mg kg(-1)) of diethyldithiocarbamate (DDTC) to rats. A single dose of DDTC caused substantial damage to the olfactory epithelium and degeneration within the olfactory bulb. The epithelium regenerates, followed by regeneration in theolfactory bulb. The mean olfactory bulb weight decreased significantly 3 days after DDTC administration and gradually recovered to control values in 6 weeks. The DDTC-induced lesion of the olfactory nerve resulted in significant changes in glutathione (GSH) and antioxidant enzyme activities in olfactory bulb. in contrast, no significant changes were found in either cerebellum or dorsal neocortex, These observations indicate that a single dose ofDDTC selectively affected the ROS scavenging system of the olfactory bulb,Moreover, these changes persisted for at least 6 weeks, which includes regeneration and synaptogenesis. Olfactory bulb GSH concentrations decreased significantly by 47 +/- 4%, glutathione reductase activity decreased by 18 +/- 3% and catalase activity increased by 27 +/- 7% over the 6 weeks. Superoxide dismutase activity decreased significantly in olfactory bulb of rats by 32 +/- 6% at 3 days following the lesion and then recovered and increasedby 38 +/- 3% at 3 weeks. Olfactory bulb malondialdehyde concentrations were elevated (298 +/- 67%) throughout the post-lesion survival period, although this change did not reach the stringent statistical significance level required in this study. These data suggest that increased ROS flux perturbs the olfactory bulb antioxidant defense system during olfactory nerve regeneration. Copyright (C) 1999 John Wiley & Sons, Ltd.

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Documento generato il 11/08/20 alle ore 03:11:08