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Titolo:
Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection
Autore:
Gisslen, M; Fuchs, D; Svennerholm, B; Hagberg, L;
Indirizzi:
Univ Gothenburg, Dept Infect Dis, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden , Dept Infect Dis, Gothenburg, Sweden Univ Gothenburg, Dept Virol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden nburg, Dept Virol, Gothenburg, Sweden Innsbruck Univ, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ochem, A-6020 Innsbruck, Austria Innsbruck Univ, Ludwig Boltzmann Inst AIDS Res, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 S Res, A-6020 Innsbruck, Austria
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
fascicolo: 4, volume: 21, anno: 1999,
pagine: 271 - 276
SICI:
1525-4135(19990801)21:4<271:CFVLII>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; AIDS DEMENTIA COMPLEX; NECROSIS-FACTOR-ALPHA; QUINOLINIC ACID; RNA LEVELS; NEUROLOGICAL DISORDERS; TRYPTOPHAN DEGRADATION; ZIDOVUDINE TREATMENT; TYPE-1 INFECTION;
Keywords:
HIV-1; CSF; neopterin; IgG index; monocytic cell count;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gisslen, M Sahlgrenska Univ Hosp, Dept Infect Dis, SE-41685 Gothenburg, Sweden Sahlgrenska Univ Hosp Gothenburg Sweden SE-41685 burg, Sweden
Citazione:
M. Gisslen et al., "Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection", J ACQ IMM D, 21(4), 1999, pp. 271-276

Abstract

To assess the association between cerebrospinal fluid (CSF) viral load, intrathecal immunoactivation, and immunosuppression in HIV-1-infected individuals with no antiretroviral treatment experience a cross-sectional study ofstored frozen CSF and plasma samples were conducted. The study population included a total of 120 antiretroviral-naive HN-l-infected patients, 110 neuroasymptomatic patients, and 10 with neurologic complications. HIV-1 RNA was quantified in cell-free CSF and plasma using polymerase chain reaction (PCR; Roche Amplicor HIV-1 Monitor version 1.5, Roche Diagnostic Systems, Hoffmann-La Roche, Inc., Basel, Switzerland). Immunoactivation was measured by CSF-serum IgG index, CSF neopterin concentrations, and CSF monocytic cellcount. The CSF HIV-1 RNA load did not differ significantly between patients with or without neurologic complications. In patients without neurologic symptoms, the CSF monocytic cell counts were correlated to the CSF viral load (r(s) = 0.40, p < .001), whereas IgG index and CSF neopterin concentrations were correlated to the viral load only in the subgroup of patients withCD4 counts greater than or equal to 200 x 10(6) cells/L. In this subgroup of patients, the peripheral CD4 cell count was, as expected, inversely correlated to the CSF viral load (r(s) = -0.36, p < .01), whereas in patients with CD4 counts <200 x 10(6) cells/L, an unexpected, significant positive correlation (r(s) = 0.43, p < .01) was found. In HIV-l-infected patients withneurologic complications, no significant correlations were found between immune activation, CSF viral load, and immunosuppression.

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Documento generato il 18/01/20 alle ore 21:56:12