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Titolo:
Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies
Autore:
Moss, DJ; Khanna, R; Sherritt, M; Elliott, SL; Burrows, SR;
Indirizzi:
Queensland Inst Med Res, Bancroft Ctr, Brisbane, Qld 4006, Australia Queensland Inst Med Res Brisbane Qld Australia 4006 , Qld 4006, Australia Univ Queensland, Epstein Barr Virus Unit, Joint Oncol Program, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia Program, Brisbane, Qld, Australia
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
, volume: 21, anno: 1999, supplemento:, 1
pagine: S80 - S83
SICI:
1525-4135(19990801)21:<S80:DISFTC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BURKITTS-LYMPHOMA CELLS; CYTOTOXIC T-CELLS; NASOPHARYNGEAL CARCINOMA; LYMPHOPROLIFERATIVE DISORDERS; EXPRESSION; EPITOPES; ANTIGEN; LYMPHOCYTES; VACCINE; SURVEILLANCE;
Keywords:
Epstein-Barr virus; immunotherapy; nasopharyngeal carcinoma; immunoblastic lymphoma; Burkitt's lymphoma; cytotoxic T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Moss, DJ Queensland Inst Med Res, Bancroft Ctr, 300 Herston Rd, Brisbane, Qld 4006,Australia Queensland Inst Med Res 300 Herston Rd Brisbane Qld Australia 4006
Citazione:
D.J. Moss et al., "Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies", J ACQ IMM D, 21, 1999, pp. S80-S83

Abstract

Epstein-Barr virus (EBV) infection is associated with various physical human malignancies. The potential for immunotherapeutic treatment by cytotoxicT cells (CTL) depends on the degree of EBV-antigen expression, with the best prospect revolving around the immunoblastic lymphomas of organ transplant patients in which adoptive transfer of in vitro reactivated CTL has already been demonstrated to be effective. Opportunities for effective immunotherapy in the treatment of nasopharyngeal carcinoma (NPC) is reduced because the available targets are limited to relatively nonimmunogenic proteins. However, analysis of NPC cells has revealed normal expression of the major histocompatibility complex (MHC)-encoded peptide transporters TAP-1 and TAP-2, together with high levels of human leukocyte antigen (HLA) class I alleles on the cell surface. Burkitt's lymphoma (BL) displays downregulated expression of MHC class I and TAP-1 and TAP-2 proteins, whereas viral antigen expression is limited to a protein incapable of processing class I CTL epitopes. It therefore seems likely that effective treatment of BL will revolve around protocols designed to reverse its undifferentiated phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:53:19