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Titolo:
The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass
Autore:
Hamano, K; Gohra, H; Katoh, T; Fujimura, Y; Zempo, N; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 755, Japan Yamaguchi Univ Ube Yamaguchi Japan 755 Surg 1, Ube, Yamaguchi 755, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 21, anno: 1999,
pagine: 531 - 540
SICI:
0192-0561(199908)21:8<531:TPAOLA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-MEDIATED RESPONSES; COMPLEMENT ACTIVATION; SUPPRESSION; HOST; THYMOPENTIN; OPERATIONS;
Keywords:
cardiac surgery; cardiopulmonary bypass; immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hamano, K Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 755, Japan Yamaguchi Univ Ube Yamaguchi Japan 755 be, Yamaguchi 755, Japan
Citazione:
K. Hamano et al., "The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass", INT J IMMUN, 21(8), 1999, pp. 531-540

Abstract

The aim of this study was to determine whether the preoperative administration of lentinan, which is used clinically to activate T cell function in cancer patients, prevents the impairment of lymphocyte function after cardiopulmonary bypass (CPB). A total of 25 adults undergoing coronary artery bypass grafting were enrolled in this study. Lentinan (2 mg) was given to 10 randomly selected patients 7 d before surgery, while the other 15 patients were considered as a control. The white blood cell count, percentage of lymphocytes, subsets of lymphocytes, and natural killer cell activity were measured preoperatively, immediately after CPB and 1, 3, and 6 d after surgery. The white blood cell counts and the percentage of lymphocytes were not significantly different between the two groups; however, the percentage of CD4-positive cells in the lentinan group recovered to normal more rapidly thanin the control group. Although natural killer cell activity was impaired in the control group after CPB, it maintained a nearly normal level in the lentinan group. The preoperative administration of lentinan for patients undergoing CPB ameliorated the impairment of natural killer activity and promoted the rapid recovery of CD4-positive cells. (C) 1999 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:42:30