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Titolo:
Developmental regulation of immunoglobulin mRNA processing and the IgA response - Establishing a paradigm
Autore:
Lebman, DA; Coyle, JH;
Indirizzi:
Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
IMMUNOLOGIC RESEARCH
fascicolo: 1, volume: 20, anno: 1999,
pagine: 43 - 53
SICI:
0257-277X(1999)20:1<43:DROIMP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MU-MESSENGER-RNA; H-CHAIN GENE; B-CELL DIFFERENTIATION; SECRETORY POLY(A) SITE; CLEAVAGE-POLYADENYLATION; ULCERATIVE-COLITIS; CROHNS-DISEASE; LYMPHOCYTES-B; TRANSCRIPTION TERMINATION; NUCLEAR FACTORS;
Keywords:
IgA; B cells; polyadenylation; splicing; mRNA processing; immunoglobulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Lebman, DA Virginia Commonwealth Univ, Dept Microbiol & Immunol, POB 980678, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980678 Richmond VAUSA 23298 USA
Citazione:
D.A. Lebman e J.H. Coyle, "Developmental regulation of immunoglobulin mRNA processing and the IgA response - Establishing a paradigm", IMMUNOL RES, 20(1), 1999, pp. 43-53

Abstract

IgA, which is protective at mucosal sites, is derived from memory B cells that develop in the organized lymphoid tissue of the gastrointestinal tractand subsequently mature to plasma cells in the lamina propria. Similarly to B cells expressing other isotypes, the maturation of IgA-expressing B cells is associated with both an increase in the steady-state level of immunoglobulin mRNA and the ratio of secreted to membrane forms of mRNA, which differ in 3' terminus. In contrast to B cells expressing other isotypes, at all stages in the development of an IgA response, the secreted form of a mRNApredominates. In this article, studies on the general features of IgA B cell development, mechanisms regulating 3' terminus usage of Ig mRNAs, and isotype-specific regulation of 3' terminus usage particularly in regard to a mRNA are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:23:11