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Titolo:
Inteferon gamma induces the expression of p21(waf-1) and arrests macrophage cell cycle, preventing induction of apoptosis
Autore:
Xaus, J; Cardo, M; Valledor, AF; Soler, C; Lloberas, J; Celada, A;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Fisiol Biol Macrofag, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 acrofag, E-08028 Barcelona, Spain Univ Barcelona, Fdn August Pi & Sunyer, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Sunyer, E-08028 Barcelona, Spain
Titolo Testata:
IMMUNITY
fascicolo: 1, volume: 11, anno: 1999,
pagine: 103 - 113
SICI:
1074-7613(199907)11:1<103:IGITEO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; PERIPHERAL-BLOOD MONOCYTES; INTERFERON-GAMMA; T-CELLS; GENE-EXPRESSION; GROWTH ARREST; G1 PHASE; IN-VIVO; SURFACE-IMMUNOGLOBULIN; P53-INDUCED APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Celada, A Univ Barcelona, Fac Biol, Dept Fisiol Biol Macrofag, Campus Bellvitge,Ave Diagonal 645, E-08028 Barcelona, Spain Univ Barcelona Campus Bellvitge,Ave Diagonal 645 Barcelona Spain E-08028
Citazione:
J. Xaus et al., "Inteferon gamma induces the expression of p21(waf-1) and arrests macrophage cell cycle, preventing induction of apoptosis", IMMUNITY, 11(1), 1999, pp. 103-113

Abstract

Incubation of bone marrow macrophages with lipopolysaccharide (LPS) or interferon gamma (IFN gamma) blacks macrophage proliferation. LPS treatment orM-CSF withdrawal arrests the cell cycle at early G(1) and induces apoptosis. Treatment of macrophages with IFN gamma stops the cell cycle later, at the G(1)/S boundary, induces p21(Waf1), and does not induce apoptosis. Moreover, pretreatment of macrophages with IFN gamma protects from apoptosis induced by several stimuli. Inhibition of p21(Waf1) with antisense oligonucleotides or using KO mice shows that the induction of p21(Waf1) by IFN gamma mediates this protection. Thus, IFN gamma makes macrophages unresponsive to apoptotic stimuli by inducing p21(Waf1) and arresting the cell cycle at theG(1)/S boundary. Therefore, the cells of the innate immune system could only survive while they were functionally active.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:41:37