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Titolo:
SCHWANN-CELL CHANGES INDUCED AS EARLY AS ONE WEEK AFTER GALACTOSE INTOXICATION
Autore:
MIZISIN AP; POWELL HC;
Indirizzi:
UNIV CALIF SAN DIEGO,SCH MED,VET ADM MED CTR LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,SCH MED,DEPT PATHOL NEUROPATHOL 0612 LA JOLLA CA92093
Titolo Testata:
Acta Neuropathologica
fascicolo: 6, volume: 93, anno: 1997,
pagine: 611 - 618
SICI:
0001-6322(1997)93:6<611:SCIAEA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSE REDUCTASE INHIBITION; PERIPHERAL-NERVE; DIABETIC RATS; NEUROPATHY; DEMYELINATION; EDEMA; LOCALIZATION; ACCUMULATION; PERMEABILITY; PATHOLOGY;
Keywords:
ALDOSE REDUCTASE; EXPERIMENTAL DIABETIC NEUROPATHY; POLYOL PATHWAY; SCHWANN CELLS; ULTRASTRUCTURAL PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
A.P. Mizisin e H.C. Powell, "SCHWANN-CELL CHANGES INDUCED AS EARLY AS ONE WEEK AFTER GALACTOSE INTOXICATION", Acta Neuropathologica, 93(6), 1997, pp. 611-618

Abstract

In galactose neuropathy, aldose reductase inhibitor (ARI)-preventableSchwann cell injury has been reported in studies in which galactose feeding continued over a period of months. Given the link between thesemorphologic changes and polyol pathway flux, polyol accumulation after just days of galactose feeding points to the possibility that structural changes occur much earlier than previously reported. The aim of this study was to examine rat sciatic nerve after 7 days of galactose feeding for evidence of myelinated fiber injury and establish whether it is related to polyol accumulation. Compared to control of ART-treated galactose-fed rats, nerves from untreated galactose-fed rats had increased water (P < 0.05) and dulcitol (P < 0.008) content and decreasedamounts of myo-inositol (P < 0.01). Electron microscopy revealed re active Schwann cell changes in myelinated fibers characterized by increased cytoplasmic volume, and the occurrence of lipid droplets, pi granules of Reich and enlarged mitochondria. Dystrophic accumulation of intermediate filaments was also observed in the inner glial loop. Degenerative changes included periaxonal swelling, enlarged mitochondria without recognizable cristae, lysis of Schwann cell cytoplasm and demyelination. Reactive (P < 0.05) and degenerative (P < 0.01) changes as well as the number of redundant basal lamina profiles (P < 0.05) were significantly more frequent in untreated galactose-fed rats compared to controls. ARI treatment attenuated these changes. Consistent with the initial stages of onion-bulb formation, profiles with imbricate Schwanncells were also seen only in untreated galactose-fed rats. The findings suggest that short-term increases in polyol pathway activity can have deleterious effects on Schwann cells of myelinated fibers.

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Documento generato il 30/09/20 alle ore 09:19:03