Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Low dose of lipopolysaccharide induces a delayed enhanced nitric oxide-mediated relaxation in rat aorta
Autore:
Pu, Q; Bordet, R; Robin, E; Puisieux, F; Vallet, B; Dupuis, B;
Indirizzi:
Fac Med Lille, Pharmacol Lab, F-59045 Lille, France Fac Med Lille Lille France F-59045 Pharmacol Lab, F-59045 Lille, France CH&U, Dept Anesthesie Reanimat, Lille, France CH&U Lille FranceCH&U, Dept Anesthesie Reanimat, Lille, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 377, anno: 1999,
pagine: 209 - 214
SICI:
0014-2999(19990721)377:2-3<209:LDOLIA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; MONOPHOSPHORYL LIPID-A; SYNTHASE MESSENGER-RNA; ENDOTHELIAL-CELLS; L-ARGININE; EXPRESSION; ENDOTOXIN; RELEASE; PROTECTION; ARTERIES;
Keywords:
lipopolysaccharide; aortic ring; endothelium; vasorelaxation; N-omega-monomethyl-L-arginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bordet, R Fac Med Lille, Pharmacol Lab, 1 Pl Verdun, F-59045 Lille, FranceFac Med Lille 1 Pl Verdun Lille France F-59045 45 Lille, France
Citazione:
Q. Pu et al., "Low dose of lipopolysaccharide induces a delayed enhanced nitric oxide-mediated relaxation in rat aorta", EUR J PHARM, 377(2-3), 1999, pp. 209-214

Abstract

Delayed effect on vascular reactivity of isolated aorta was studied after injection of a single low dose of lipopolysaccharide (0.5 mg/kg i.p.). The maximal vascular effect was observed 72 h after lipopolysaccharide administration with an increase in maximal endothelium-dependent relaxing response to acetylcholine and parallelly a decrease in contractile response to phenylephrine. The change in contractile response was nullified by endothelium removal as well by in vitro aortic rings incubation with N-omega-monomethyl-L-arginine but not with indomethacin. A low dose of lipopolysaccharide induces a delayed enhanced nitric oxide-mediated vascular relaxation which could contribute to its delayed anti-ischemic properties in ischemic tolerance phenomenon. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:18:47