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Titolo:
Development of a "continuous-flow adhesion cell" for the assessment of hydrogel adhesion
Autore:
Le Ray, AM; Iooss, P; Gouyette, A; Vonarx, V; Patrice, T; Merle, C;
Indirizzi:
Fac Pharm, Pharm Galen Lab, F-44035 Nantes, France Fac Pharm Nantes France F-44035 Pharm Galen Lab, F-44035 Nantes, France CHU Nantes, Dept Laser, F-44093 Nantes 1, France CHU Nantes Nantes France 1 Nantes, Dept Laser, F-44093 Nantes 1, France
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 8, volume: 25, anno: 1999,
pagine: 897 - 904
SICI:
0363-9045(1999)25:8<897:DOA"AC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED DRUG-DELIVERY; POLYACRYLIC-ACID; POLY(ACRYLIC ACID); CONTROLLED-RELEASE; DOSAGE FORMS; BIOADHESIVE; SYSTEMS; MUCOADHESION; ABSORPTION; POLYMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Le Ray, AM Fac Pharm, Pharm Galen Lab, 1 Rue Gaston Veil, F-44035 Nantes, France Fac Pharm 1 Rue Gaston Veil Nantes France F-44035 ntes, France
Citazione:
A.M. Le Ray et al., "Development of a "continuous-flow adhesion cell" for the assessment of hydrogel adhesion", DRUG DEV IN, 25(8), 1999, pp. 897-904

Abstract

The purpose of this study was to develop an in vitro perfusion technique or ''continuous-flow adhesion cell" model to predict the in vivo performances of different mucoadhesive drug delivery systems based on hydrogels. Two studies were performed, either using a rabbit small intestine or a polyethylene surface; the adhesion of four gels-two poly(acrylic acid)s (PAAs) (carbomer [CM] mid polycarbophil [PC]), an ethyleneoxide-propyleneoxide block copolymer (Poloxamer(R) 407 [PM]), and a polysaccharide (scleroglucane [SG])-were evaluated. In this respect, scleroglucane was used as a control. The adhesiveness of the different gels for both supports is in accordance with that described in the literature, that is, polycarbophil adhered more strongly than carbomer, which itself adhered more strongly than poloxamer. This study proved that the gels adhere more strongly to the polyethylene tube than to the rabbit small intestine, thus indicating that evidence for adhesionproperties does not need ally presence of mucus. Therefore, our in vitro model could be a good method, more precise and more simple than an ex vivo technique, to predict the bioadhesion of gelified devices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:41:28