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Titolo:
Inhibition of the human primary motor area by painful heat stimulation of the skin
Autore:
Valeriani, M; Restuccia, D; Di Lazzaro, V; Oliviero, A; Profice, P; Le Pera, D; Saturno, E; Tonali, P;
Indirizzi:
Catholic Univ Sacred Heart, Dept Neurol, I-00168 Rome, Italy Catholic UnivSacred Heart Rome Italy I-00168 eurol, I-00168 Rome, Italy IRCCS, CSS Hosp, San Giovanni Rotondo, Italy IRCCS San Giovanni Rotondo Italy CSS Hosp, San Giovanni Rotondo, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 8, volume: 110, anno: 1999,
pagine: 1475 - 1480
SICI:
1388-2457(199908)110:8<1475:IOTHPM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; EVOKED CEREBRAL POTENTIALS; ELECTRICAL SOURCE ANALYSIS; ROSTRAL BRAIN-STEM; SILENT PERIOD; CO2-LASER STIMULATION; CUTANEOUS STIMULATION; SPATIAL RELATIONSHIPS; LATERAL DIENCEPHALON; SOMATOSENSORY CORTEX;
Keywords:
pain; motor cortex; inhibition; laser EPs; SII area; human brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Valeriani, M Catholic Univ Sacred Heart, Dept Neurol, Lgo A Gemelli 8, I-00168 Rome, Italy Catholic Univ Sacred Heart Lgo A Gemelli 8 Rome Italy I-00168
Citazione:
M. Valeriani et al., "Inhibition of the human primary motor area by painful heat stimulation of the skin", CLIN NEU, 110(8), 1999, pp. 1475-1480

Abstract

Objective: To prove whether painful cutaneous stimuli can affect specifically the motor cortex excitability. Methods: The electromyographic (EMG) responses, recorded from the first dorsal interosseous muscle after either transcranial magnetic or electric anodal stimulation of the primary motor (MI) cortex, was conditioned by both painful and non-painful CO2 laser stimuli delivered on the hand skin. Results: Painful CO2 laser stimuli reduced the amplitude of the EMG responses evoked by the transcranial magnetic stimulation of both the contralateral and ipsilateral MI areas; This inhibitory effect followed the arrival ofthe nociceptive inputs to cerebral cortex. Instead, the EMG response amplitude was not significantly modified either when it was evoked by the motor cortex anodal stimulation or when nonpainful CO2 laser pulses were used as conditioning stimuli. Conclusions: Since the magnetic stimulation leads to transynaptic activation of pyramidal neurons, while the anodal stimulation activates directly cortico-spinal axons, the differential effect of the noxious stimuli on the EMG responses evoked by the two motor cortex stimulation techniques suggeststhat the observed inhibitory effect has a cortical origin. The bilateral cortical representation of pain explains why the painful CO2 laser stimuli showed a conditioning effect on MI area of both hemispheres. Non-painful CO2laser pulses did not produce any effect, thus suggesting that the reduction of the MI excitability was specifically due to the activation of nociceptive afferents. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:11:53