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Titolo:
Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications
Autore:
Wang, SM; Liu, CC; Tseng, HW; Wang, JR; Huang, CC; Chen, YJ; Yang, YJ; Lin, SJ; Yeh, TF;
Indirizzi:
Natl Cheng Kung Univ Hosp, Dept Pediat, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp Tainan Taiwan 70428 diat, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp, Dept Emergency Med, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp Tainan Taiwan 70428 Med, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp Tainan Taiwan 70428 thol, Tainan 70428, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Pediat, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 pt Pediat, Tainan 70101, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Med Technol, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 d Technol, Tainan 70101, Taiwan
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 1, volume: 29, anno: 1999,
pagine: 184 - 190
SICI:
1058-4838(199907)29:1<184:CSOE7I>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NEUROGENIC PULMONARY-EDEMA; MOUTH-DISEASE; OUTBREAK; PARALYSIS; HAND; FOOT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, CC Natl Cheng Kung Univ Hosp, Dept Pediat, 138 Sheng Li Rd, Tainan 70428, Taiwan Natl Cheng Kung Univ Hosp 138 Sheng Li Rd Tainan Taiwan 70428 wan
Citazione:
S.M. Wang et al., "Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications", CLIN INF D, 29(1), 1999, pp. 184-190

Abstract

An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pens, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosisin this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:55:10