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Titolo:
A NEWLY IDENTIFIED MEMBER OF THE TUMOR-NECROSIS-FACTOR RECEPTOR SUPERFAMILY WITH A WIDE TISSUE DISTRIBUTION AND INVOLVEMENT IN LYMPHOCYTE-ACTIVATION
Autore:
KWON BS; TAN KB; NI J; KWIOKOH; LEE ZH; KIM KK; KIM YJ; WANG S; GENTZ R; YU GL; HARROP J; LYN SD; SILVERMAN C; PORTER TG; TRUNEH A; YOUNG PR;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,WALTHER ONCOL CTR INDIANAPOLIS IN 46202 DEPT MOL IMMUNOL KING OF PRUSSIA PA 19406 HUMAN GENOME SCI INC ROCKVILLE MD 20850
Titolo Testata:
The Journal of biological chemistry
fascicolo: 22, volume: 272, anno: 1997,
pagine: 14272 - 14276
SICI:
0021-9258(1997)272:22<14272:ANIMOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; CELL ANTIGEN 4-1BB; HUMAN B-CELLS; MOLECULAR-CLONING; TNF RECEPTOR; CHROMOSOMAL LOCALIZATION; INSITU HYBRIDIZATION; HUMAN GENOME; CD40 LIGAND; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Kwon et al., "A NEWLY IDENTIFIED MEMBER OF THE TUMOR-NECROSIS-FACTOR RECEPTOR SUPERFAMILY WITH A WIDE TISSUE DISTRIBUTION AND INVOLVEMENT IN LYMPHOCYTE-ACTIVATION", The Journal of biological chemistry, 272(22), 1997, pp. 14272-14276

Abstract

The tumor necrosis factor receptor (TNFR) superfamily consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base, cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase formwas most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22-36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frameencodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4-1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:43:20