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Titolo:
Yohimbine use in a natural setting: Effects on posttraumatic stress disorder
Autore:
Southwick, SM; Morgan, CA; Charney, DS; High, JR;
Indirizzi:
VA CT Healthcare Syst, Psychiat Serv 116A, W Haven, CT 06516 USA VA CT Healthcare Syst W Haven CT USA 06516 rv 116A, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Univ So Calif, Sch Med, Dept Psychiat, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 sychiat, Los Angeles, CA 90033 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 46, anno: 1999,
pagine: 442 - 444
SICI:
0006-3223(19990801)46:3<442:YUIANS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANISMS;
Keywords:
posttraumatic stress disorder; naturalistic; yohimbine; norepinephrine; sensitization; flashback;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Southwick, SM VA CT Healthcare Syst, Psychiat Serv 116A, 950 Campbell, W Haven, CT 06516USA VA CT Healthcare Syst 950 Campbell W Haven CT USA 06516 6USA
Citazione:
S.M. Southwick et al., "Yohimbine use in a natural setting: Effects on posttraumatic stress disorder", BIOL PSYCHI, 46(3), 1999, pp. 442-444

Abstract

Background: Numerous laboratory-based studies have shown that chronic posttraumatic stress disorder (PTSD) is associated with alterations in catecholamines. In a recent neuroendocrine challenge study, IV yohimbine caused exaggerated subjective, behavioral, cardiovascular and catecholamine responsesamong combat veterans with PTSD compared to healthy controls. Yohimbine isan alpha-2-adrenergic receptor antagonist that activates noradrenergic neurons. Methods: This report describes the experience of 4 individuals with PTSD who took over-the-counter oral yohimbine that they had purchased from a health food store or pharmacy. Results: All 4 subjects experienced a marked exacerbation of anxiety/panicand PTSD-specific symptoms immediately after ingesting yohimbine in a natural setting. Conclusions: The response in these individuals closely resembled the response observed after IV yohimbine in combat veterans with PTSD. The present cases occurred in a natural setting and thus complement laboratory-based findings. The authors caution against the recreational or medical use of yohimbine in individuals who have PTSD. Biol Psychiatry 1999;46:442-444 (C) 1999Society of Biological Psychiatry.

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Documento generato il 22/01/20 alle ore 21:48:21