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Titolo:
Does neurotensin mediate the effects of antipsychotic drugs?
Autore:
Kinkead, B; Binder, EB; Nemeroff, CB;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 46, anno: 1999,
pagine: 340 - 351
SICI:
0006-3223(19990801)46:3<340:DNMTEO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT NUCLEUS-ACCUMBENS; REGIONAL BRAIN CONCENTRATIONS; VENTRAL TEGMENTAL AREA; RECEPTOR MESSENGER-RNA; BINDING-SITES; DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; ANIMAL-MODEL; AUTORADIOGRAPHIC DISTRIBUTION;
Keywords:
schizophrenia; clinical efficacy; extrapyramidal side effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Nemeroff, CB Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Woodruff Mem Res Bldg,1639 Pierce Dr,Suite 4000, Atlanta, GA 30322 USA Emory Univ Woodruff Mem Res Bldg,1639 Pierce Dr,Suite 4000 AtlantaGA USA 30322
Citazione:
B. Kinkead et al., "Does neurotensin mediate the effects of antipsychotic drugs?", BIOL PSYCHI, 46(3), 1999, pp. 340-351

Abstract

The possibility that the neuropeptide neurotensin (NT) may function as an endogenous antipsychotic compound was first hypothesized almost two decadesago. Since that time, considerable effort has been directed towards determining whether NT neurons mediate the effects of antipsychotic drugs (APDs). The anatomic, biochemical, behavioral, and clinical relevance of this hypothesis is reviewed. Although the majority of the available evidence is indirect the availability of several NT receptor (NTR) antagonists have now made possible the direct examination of the involvement of the NT system in the mechanism of action of APDs. Preliminary studies in our laboratory demonstrate the ability of a selective NTR antagonist to block the effects of APDs in two models of sensory motor gating deficits characteristic of schizophrenia. These data, taken together with a compelling series of studies demonstrating that increases of NT/neuromedin N mRNA expression and NT content in the nucleus accumbens and striatum after chronic administration of APDs are predictive of clinical efficacy and extrapyramidal side effects, respectively, provide direct preclinical evidence for a role of the NT system in the clinical efficacy of APDs. Although effects of selective NTR antagonistsin normal volunteers or schizophrenic patients have not been studied, and nonpeptidergic NTR agonists have not yet been identified, these cumulative results provide the groundwork for the use of NT-ergic compounds in the treatment of schizophrenia. Biol Psychiatry 1999;46:340-351 (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:59:33